79713-08-9Relevant academic research and scientific papers
Spiroindolone analogues as potential hypoglycemic with dual inhibitory activity on α-amylase and α-glucosidase
Altowyan, Mezna Saleh,Barakat, Assem,Al-Majid, Abdullah Mohammed,Al-Ghulikah
, (2019)
Inhibition of α-amylase and α-glucosidase by specified synthetic compounds during the digestion of starch helps control post-prandial hyperglycemia and could represent a potential therapy for type II diabetes mellitus. A new series of spiroheterocyclic co
A boron-nitrogen transborylation enabled, borane-catalysed reductive cyanation of enones
Benn, Kieran,Nicholson, Kieran,Langer, Thomas,Thomas, Stephen P.
supporting information, p. 9406 - 9409 (2021/09/22)
Cyanation offers a simple method for the introduction of a nitrile group into organic molecules and an orthogonal route for the installation of a wide array of functional groups using simple transformations. Cyanation methods are dominated by transition metal catalysis and the use of hydrogen cyanide gas. Here, the electrophilic cyanation of enones was achieved using a main-group catalyst and a non-toxic, electrophilic cyanide source. This protocol was applied across a broad substrate scope including those containing reducible functional groups. Mechanistic studies indicated an amino-borane intermediate which underwent B-N transborylation (B-N/B-H exchange) to achieve catalytic turnover.
