79751-03-4Relevant academic research and scientific papers
N-Acyl Dehydro-α-amino Acids from N-Formyl Dehydro-α-amino Acid Esters
Schoellkopf, Ulrich,Meyer, Rolf
, p. 1469 - 1475 (2007/10/02)
On treatment with methyl potassioisocyanoacetate (2), aldehydes and ketones 1 give N-anionized N-formyl dehydro-α-amino acid methyl esters 3.Compounds 3 with R1 = CH3, R2 = H is obtained by base induced ring opening of methyl 2-oxazoline-4-carboxylate 5. - Acylation of 3, followed by deformation of the intermediates 6, yields N-acyl dehydro α-amino acid methyl esters 7 which can be hydrolyzed to the N-acyl dehydro α-amino-acids 8.
