79763-29-4Relevant academic research and scientific papers
Versatile synthesis of epicatechin series procyanidin oligomers, and their antioxidant and DNA polymerase inhibitory activity
Saito, Akiko,Mizushina, Yoshiyuki,Tanaka, Akira,Nakajima, Noriyuki
experimental part, p. 7422 - 7428 (2009/12/24)
Proanthocyanidins, known as condensed tannins or oligomeric flavonoids, exist in many edible plants and show various interesting biological activities. We have developed a simple and versatile method of synthesizing procyanidin oligomers consisting of (-)
Synthesis of Condensed Tannins. Part 13. The First 2,3-trans-3,4-cis-Procyanidins: Sequence of Units in a 'Trimer' of Mixed Stereochemistry
Delcour, Jan A.,Serneels, Edward J.,Ferreira, Daneel,Roux, David G.
, p. 669 - 676 (2007/10/02)
The condensation of (+)-leucocyanidin with (-)-epicatechin initiates a succession of substitutions leading mainly to the introduction of -2,3-trans-3,4-procyanidin units, but also to the incorporation of 'terminal' moieties which possess the hitherto unique 3,4-cis-procyanidin configuration.The bonding patterns in the products, and also the sequence of units in one of the 'trimers' of mixed stereochemistry, are resolved by (1)H n.m.r. spectroscopy through selective use of solvents at elevated temperatures.
