797783-30-3Relevant academic research and scientific papers
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors
Li, Qun,Claiborne, Akiyo,Li, Tongmei,Hasvold, Lisa,Stoll, Vincent S.,Muchmore, Steven,Jakob, Clarissa G.,Gu, Wendy,Cohen, Jerry,Hutchins, Charles,Frost, David,Rosenberg, Saul H.,Sham, Hing L.
, p. 5367 - 5370 (2007/10/03)
As a part of our efforts to identify potent inhibitors of farnesyltransferase (FTase), modification of the structure of tipifarnib through structure-based design was undertaken by replacing the 2-quinolones with 4-quinolones and pyridones, and subsequent
