797788-19-3Relevant academic research and scientific papers
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore
Johns, Brian A.,Weatherhead, Jason G.,Allen, Scott H.,Thompson, James B.,Garvey, Edward P.,Foster, Scott A.,Jeffrey, Jerry L.,Miller, Wayne H.
scheme or table, p. 1802 - 1806 (2009/12/01)
A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-metal
NAPHTHYRIDINE INTEGRASE INHIBITORS
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Page 53-54, (2010/02/09)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
