20228-87-9Relevant articles and documents
Transition-Metal-Free α Csp3?H Cyanation of Sulfonamides
Zhou, Liejin,Wei, Siqi,Lei, Ziran,Zhu, Gangguo,Zhang, Zuxiao
, p. 7103 - 7107 (2021/04/16)
This report describes the site-selective α-functionalization of sulfonylamide derivatives through the in-situ generation of imine intermediates. The N?F sulfonylamides, which could facilitate the elimination to generate imines, are coupled with TBACN to e
The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore
Johns, Brian A.,Weatherhead, Jason G.,Allen, Scott H.,Thompson, James B.,Garvey, Edward P.,Foster, Scott A.,Jeffrey, Jerry L.,Miller, Wayne H.
scheme or table, p. 1802 - 1806 (2009/12/01)
A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-metal
Benzotriazole-assisted synthesis of N-(α-cyanoalkyl)sulfonamides
Katritzky, Alan R.,Oniciu, Daniela C.,Ghiviriga, Ion
, p. 907 - 922 (2007/10/03)
N-(α-benzotriazol-1-ylalkyl)sulfonamides, readily available from benzotriazole, an aldehyde and a sulfonamide, are converted into the corresponding N-(α-cyanoalkyl)sulfonamides in good yields by treatment with potassium cyanide.