20228-87-9

Usage

Uses

Used in Pharmaceutical Industry:
Benzenesulfonamide, N-(cyanomethyl)-4-methylis used as an intermediate in the synthesis of various pharmaceuticals and drugs, leveraging its antimicrobial properties to contribute to the development of new therapeutic agents.
Used in Dye and Pigment Production:
This chemical compound serves as an intermediate in the production of dyes and pigments, where its chemical structure and reactivity are harnessed to create a variety of colorants for different applications.
Used in Materials Science and Organic Chemistry:
Benzenesulfonamide, N-(cyanomethyl)-4-methylis utilized in research and development within the fields of materials science and organic chemistry due to its potential to participate in diverse chemical reactions, offering new pathways for creating innovative materials and compounds.

Upstream product

• 50-00-0 formaldehyd 
• 143-33-9 sodium cyanide 
• 70-55-3 toluene-4-sulfonamide 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 151-50-8 potassium cyanide 
• 540-61-4 2-aminoacetonitrile 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 88303-12-2 N-fluoro-N-methyl-p-toluene sulfonamide 
• 640-61-9 N-methyl-p-toluenesulfonylamide 

Downstream Products

• 103640-06-8 2-(toluene-4-sulfonylamino)-acetimidic acid ethyl ester 
• 1372807-25-4 (9H-fluoren-9-yl)methyl 4-tosyl-2-vinylpiperazine-1-carboxylate 
• 1384175-20-5 C₁₃H₁₈N₂O₂S 
• 1372807-09-4 (E)-9H-fluoren-9-ylmethyl 2-(N-(4-hydroxybut-2-en-1-yl)-4-methylphenylsulfonamidoethyl)carbamate 
• 1372807-08-3 (E)-N-cyanomethyl-4-methyl-N-(4-tetrahydro-2H-pyran-2-yloxybut-2-en-1-yl)benzenesulfonamide 
• 1266340-80-0 N-(cyanomethyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide 
• 1307725-89-8 N-(cyanomethyl)-N-(3-phenylprop-2-yn-1yl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Transition-Metal-Free α Csp3?H Cyanation of Sulfonamides

This report describes the site-selective α-functionalization of sulfonylamide derivatives through the in-situ generation of imine intermediates. The N?F sulfonylamides, which could facilitate the elimination to generate imines, are coupled with TBACN to e

Photoredox transformations with dimeric gold complexes

Let the sunshine in! Unactivated alkyl and aryl bromides underwent a light-enabled reductive radical cyclization in the presence of a dimeric phosphine-gold complex as a photocatalyst (see scheme; X=C(CO 2Et)2, NR, O). Sunlight can be used as the energy source for this simple and efficient radical reaction, which does not require potentially hazardous and toxic chemical reagents, such as organostannanes and chemical initiators.

The use of oxadiazole and triazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 1: Establishing the pharmacophore

A series of HIV-1 integrase inhibitors containing a novel metal binding motif consisting of the 8-hydroxy-1,6-naphthyridine core and either an oxadiazole or triazole has been identified. The design of the key structural components was based on a two-metal

NAPHTHYRIDINE INTEGRASE INHIBITORS

The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Benzotriazole-assisted synthesis of N-(α-cyanoalkyl)sulfonamides

N-(α-benzotriazol-1-ylalkyl)sulfonamides, readily available from benzotriazole, an aldehyde and a sulfonamide, are converted into the corresponding N-(α-cyanoalkyl)sulfonamides in good yields by treatment with potassium cyanide.