79786-34-8 Usage
Uses
Used in Pharmaceutical Industry:
AMidepsine D is used as a therapeutic agent for the management and prevention of diet-induced obesity and insulin resistance. Its ability to inhibit DGAT activity and reduce triacylglycerol formation makes it a promising candidate for treating metabolic disorders associated with obesity and insulin resistance.
Biological Activity
amidepsine d is a fungal metabolite isolated from the culture broth of humicola sp fo-2942. amidepsine a is an inhibitor of dylglycerol acyltransferase (dgat).dylglycerol acyltransferase (dgat) has been involved in catalyzing the formation of triglycerides from diacylglycerol and acyl-coa. the reaction is considered the terminal and only committed step in triglyceride synthesis and is essential for the formation of adipose tissue. there are two isozymes of dgat have been identified: dgat1 and dgat2. dgat-1 deficient mice are lean and resistant to the development of diet-induced obesity or insulin resistance [1]. dgat2-/- mice demonstrate reduced triglyceride levels and suffer from skin barrier abnormalities [2].fo-2942 inhibited dgat activity with an ic50 of 10.2 μm in rat liver microsomes. fo-2942 inhibited triacylglycerol formation in raji cells with the ic50 value of 15.5 μm [1].
Check Digit Verification of cas no
The CAS Registry Mumber 79786-34-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,7,8 and 6 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 79786-34:
(7*7)+(6*9)+(5*7)+(4*8)+(3*6)+(2*3)+(1*4)=198
198 % 10 = 8
So 79786-34-8 is a valid CAS Registry Number.
79786-34-8Relevant academic research and scientific papers
2,4-Di-O-methylgyrophoric Acid and 2,4,5-Tri-O-methylhiascic Acid. New Tridepsides from Parmelia damaziana
Elix, John A.,Jayanthi, Vilas K.,Leznoff, Clifford C.
, p. 1757 - 1761 (2007/10/02)
The new tridepsides 2,4-di-O-methylgyrophoric acid (8) and 2,4,5-tri-O-methylhiascic acid (5) in addition to the known metabolites atranorin (9), chooroatranorin (10), ursolic acid (11), 5-O-methylhiascic acid (4) and gyrophoric acid (7) have been isolate
