79817-66-6

Usage

Melting point

93-95°C

Boiling point

207-209°C
Aromatic compound
Used in synthesis of various organic compounds
Toxic and may cause irritation to skin, eyes, and respiratory system.

Upstream product

• 2217-40-5 1,2,3,4-tetrahydronaphthalen-1-amine 
• 119-64-2 tetralin 
• 223396-65-4 1-bromo-2-(4-nitrobutyl)benzene 
• 823809-83-2 2-bromo-α-(nitromethyl)benzenepropanol 
• 107408-16-2 3-(o-bromophenyl)propanal 

Downstream Products

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 213924-50-6 (+)-3',3'-dimethyl-1'-[(4-methylphenyl)sulfonyl]spiro[tetralin-1,5'-piperazine] 
• 213924-46-0 3',3'-dimethyl-2'-oxo-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] 
• 213924-48-2 3',3'-dimethyl-1'-((1S)-phenylethyl)spiro[tetralin-1,5'-piperazine] 
• 213924-45-9 1-[((S)-1-Phenyl-ethylamino)-methyl]-1,2,3,4-tetrahydro-naphthalen-1-ylamine 
• 213924-44-8 (1-Nitro-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-((S)-1-phenyl-ethyl)-amine 
• 135498-91-8 (E)-1-methyl 2-(1,2,3,4-tetrahydro 1-naphthalenylidenemethyl) 5-nitroimidazole 
• 2217-40-5 1,2,3,4-tetrahydronaphthalen-1-amine 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular α-arylation of aliphatic ketone, formyl, and nitro groups

Intramolecular arylation of properly designed substrates bearing a ketone, formyl, or nitro terminating group was achieved by use of a PdCl 2(Ph3P)2-Cs2CO3 reaction system to form a variety of carbocyclic compounds. Arylation in ketone compounds afforded benzene-annulated bridged or spirocycloalkanone derivatives, depending on the structure of the cyclization precursors. Arylation in formyl compounds occurred at the α-position (α-arylation) or at the carbonyl carbon (carbonyl-arylation) depending on the structure of the cyclization precursors and on the reaction solvent. An α-arylated secondary nitro group was partially transformed to ketone in the manner of the Nef reaction, whereas a tertiary nitro group was partially eliminated to afford a styrene-type olefin. Graphical Abstract

Synthesis by the S(RN)1 reaction of a new series of imidazo[1,2-a]pyridine derivatives with pharmacological potentialities

The study of S(RN)1 reaction between 2-chloromethyl-3-nitroimidazo[1,2-a] pyridine and 2-nitropropane salts has been extended to various aliphatic, cyclic and heterocyclic nitronate anions. From C-alkylation products, base-promoted nitrous acid elimination afforded new potential pharmacological derivatives with a trisubstituted double bond at the 2 position.

S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes

1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.

1,2,3,4-Tetrahydronaphthalene derivatives

New compounds of the formula: STR1 wherein R1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R2 and R3 each represent a hydrogen atom or a C1 -C4 alkyl group, and R4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.