107408-16-2

Usage

Uses

Used in Organic Synthesis:
3-(2-BROMO-PHENYL)-PROPIONALDEHYDE is used as a key intermediate in the synthesis of various organic compounds for [application reason]. Its unique structure and reactivity make it suitable for a wide range of chemical reactions, contributing to the development of new molecules and materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(2-BROMO-PHENYL)-PROPIONALDEHYDE is used as a building block for the development of new drugs and pharmaceutical agents. Its chemical properties allow it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and targeting specific biological pathways.
Used in Chemical Research:
3-(2-BROMO-PHENYL)-PROPIONALDEHYDE is utilized as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studying various chemical reactions and exploring new synthetic routes.
Used in Specialty Chemicals Production:
3-(2-BROMO-PHENYL)-PROPIONALDEHYDE is employed as a raw material in the production of specialty chemicals, such as dyes, pigments, and fragrances. Its specific chemical properties enable the creation of unique compounds with desired characteristics for various applications.

InChI:InChI=1/C9H9BrO/c10-9-6-2-1-4-8(9)5-3-7-11/h1-2,4,6-7H,3,5H2

Upstream product

• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 583-55-1 1-Bromo-2-iodobenzene 
• 107-18-6 allyl alcohol 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 66191-86-4 3-(2-bromophenyl)propanoic acid,methyl ester 
• 201230-82-2 carbon monoxide 
• 2039-88-5 2-bromostyrene 
• 20461-86-3 2,2-diethoxy acetic acid 
• 99134-25-5 (E:Z)-3-(2-bromo-phenyl)-acrylic acid ethyl ester 
• 6630-33-7 ortho-bromobenzaldehyde 
• 135613-33-1 3-(2-bromophey)propionic acid ethyl ester 
• 58380-12-4 <(2-bromophenyl)methyl>propanedicarboxylic acid 
• 15115-58-9 3-(2-bromophenyl)propionic acid 
• 66192-11-8 diethyl 2-(2-bromobenzyl)propan-1,3-dioate 

Downstream Products

• 67130-96-5 4-(2-bromophenyl)-2-butanol 
• 137265-95-3 3-(2-bromophenyl)propanal O-methyloxime 
• 107408-17-3 ethyl 7-(2-bromophenyl)-3-oxo-2-(triphenylphosphoranylidine)-4(E)-heptenoate 
• 164020-80-8 Benzyl-[3-(2-bromo-phenyl)-prop-(E)-ylidene]-amine 
• 52221-92-8 3-(2-bromo-phenyl)-propan-1-ol 
• 191795-63-8 [(Z)-6-(2-Bromo-phenyl)-hex-3-enyloxy]-tert-butyl-dimethyl-silane 
• 188004-30-0 5-(o-bromophenyl)pent-1-en-3-ol 
• 595577-75-6 1-bromo-2-(3,3-diethoxypropyl)benzene 
• 710980-33-9 1-Bromo-2-((Z)-7-chloro-hept-3-enyl)-benzene 
• 823809-83-2 2-bromo-α-(nitromethyl)benzenepropanol 
• 880477-70-3 Z-7-(2-bromophenyl)hept-4-enoic acid ethyl ester 

Relevant academic research and scientific papers

Hydroacenes Made Easy by Gold(I) Catalysis

A novel strategy for the synthesis of partially saturated acene derivatives has been developed based on a AuI-catalyzed cyclization of 1,7-enynes. This method provides straightforward access to stable polycyclic products featuring the backbone of the acene series, up to nonacene.

The Hancock Alkaloids (-)-Cuspareine, (-)-Galipinine, (-)-Galipeine, and (-)-Angustureine: Asymmetric Syntheses and Corrected 1H and 13C NMR Data

The asymmetric syntheses of all members of the Hancock alkaloid family based upon a 2-substituted N-methyl-1,2,3,4-tetrahydroquinoline core are delineated. The conjugate addition of enantiopure lithium N-benzyl-N-(α-methyl-p-methoxybenzyl)amide to 5-(o-br

Enantioselective Palladium-Catalyzed Intramolecular α-Arylative Desymmetrization of 1,3-Diketones

An efficient enantioselective protocol has been reported to build highly oxygenated and densely substituted bicyclo[m.n.1] skeletons through intramolecular asymmetric α-arylative desymmetrization of 1,3-diketones. Employing Pd catalyst and FOXAP ligand, various bicyclo[m.n.1] skeleton with different size can be accessed with high enantio- and diastereoselectivities. Utilizing the present method as a key step, formal asymmetric total synthesis of the (-)-parvifoline has been demonstrated.

Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines

The first systematic study of simple nitronate nucleophiles in iridium-catalyzed allylic alkylation is described. Using a tol-BINAP-modified π-allyliridiumC,O-benzoate catalyst, α,α-disubstituted nitronates substitute racemic branched alkyl-substituted al

Remote Functionalization of α,β-Unsaturated Carbonyls by Multimetallic Sequential Catalysis

The remote functionalization of α,β-unsaturated carbonyls by an array of multimetallic sequential catalytic systems is described. The reactions are triggered by hydrometalation using [Pd-H] or [Ru-H] isomerization catalysts and driven by the formation of thermodynamically more stable 1,2-vinyl arenes. The Pd-catalyzed deconjugative isomerization was combined with a Cu-catalyzed β-borylation of the transiently generated styrenyl derivatives to deliver a range of products that would not be accessible with the use of a single catalyst. [Pd/Cu] catalytic systems were also identified for the highly enantioselective α-hydroboration and α-hydroamination of the styrenyl intermediates. Difunctionalization simultaneously at the benzylic and homobenzylic positions was achieved by combining the isomerization process with Sharpless asymmetric dihydroxylation (SAD) using [Pd/Os] or [Ru/Os] couples. Starting from a simple α,β-unsaturated ester, an isomerization/dihydroxylation/lactonization sequence gave access to a naturally occurring γ-butyrolactone in good yield, with excellent diastereo- and enantioselectivity.

Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

Direct Access to N-tert-Butanesulfinyl Imines from Aryl Iodides, Alkenyl Alcohols, and N-tert-Butanesulfinamide

The reaction of aryl iodides, N-tert-butanesulfinamide, and allyl or homoallyl alcohol in the presence of a catalytic amount of Pd(OAc)2, NaHCO3 as a base, and TBAB leads to the formation of N-tert-butanesulfinyl imines in moderate yields. In this one-pot process, a sequential Heck-type arylation of the alkenol, isomerization of the double bond, and imine formation take place.

FUNCTIONALIZED MAGNETIC NANOPARTICLE, A CATALYST, A METHOD FOR FORMING C-C BONDS

A functionalized magnetic nanoparticle including an organometallic sandwich compound and a magnetic metal oxide. The functionalized magnetic nanoparticle may be reacted with a metal precursor to form a catalyst for various C—C bond forming reactions. The catalyst may be recovered with ease by attracting the catalyst with a magnet.