79823-26-0Relevant academic research and scientific papers
Catalyzed Reaction of Diazodiphenylethanone and Related Diazo Ketones with Enaminones as a Source of Pyrroles
Eberlin, Marcos N.,Kascheres, Concetta
, p. 2084 - 2086 (2007/10/02)
The reaction of copper(II)-stabilized keto carbenes (1, 7, 8), derived from diazo ketones, with enaminones leads to the formation of pyrroles.The cyclic enaminones 3 react with the keto carbenes on nitrogen to form products 5, 9, 11, and/or pyrroles 6, 10
Heterocycles from Nitroalkenes, I. - Pyrroles via Michael Addition of Enamines
Meyer, Horst
, p. 1534 - 1544 (2007/10/02)
The principle of a general pyrrole synthesis via cyclising Michael addition of enamines to nitroalkenes is outlined.Condensation of the nitroalkene 7 with various enamines yields the pyrroles 9, 11, 12, 14, 15, 17, 18, 20, 22, 26, 27, 29, and 31.Reaction of 1-nitro-1,2-diphenylethene and the enamine 8 furnishes the pyrroloisoquinoline 32 while addition of 8 to 1-nitrocyclohexene is followed by ring closure to the indoloisoquinoline 33.The pyrrole 14 can also be prepared by multiple-component syntheses, further examples of which are the syntheses of the pyrroles 35, 36, 37, and 38.Scope and advantages of the presented pyrrole synthesis are discussed.
