79831-77-9 Usage
Chemical class
Indolizine derivatives
1,6,7,8-Indolizinetetrol, octahydro-, tetraacetate (ester), (1S,6S,7R,8R,8aR)- belongs to a group of chemical compounds derived from indolizine, a tricyclic aromatic organic compound.
Octahydro derivative
The compound is an octahydro derivative of indolizine, meaning it has eight hydrogen atoms added to the indolizine structure.
Tetraacetate (ester)
The compound has four acetate groups attached to it, making it a tetraacetate ester.
Stereochemistry
1S, 6S, 7R, 8R, and 8aR configuration
The compound has a specific arrangement of its chiral centers, which is important for its potential applications and interactions with other molecules.
Chiral centers
Five chiral centers
The compound has five chiral centers, which contribute to its stereochemistry and potential biological activity.
Potential applications
Pharmaceutical industry or synthesis of other compounds
The compound may have potential uses in the pharmaceutical industry or as a building block for the synthesis of other compounds.
Further research
Properties and uses to be determined
The specific properties and potential uses of 1,6,7,8-Indolizinetetrol, octahydro-, tetraacetate (ester), (1S,6S,7R,8R,8aR)- may be determined through further research and investigation.
Molecular structure
Tricyclic aromatic compound with ester functional groups
The compound has a complex molecular structure, featuring a tricyclic aromatic core and ester functional groups attached to it.
Solubility
Unknown, may depend on the solvent and concentration
The solubility of 1,6,7,8-Indolizinetetrol, octahydro-, tetraacetate (ester), (1S,6S,7R,8R,8aR)- is not provided, but it may vary depending on the solvent and concentration used.
Stability
Unknown, may require specific conditions for stability
The stability of 1,6,7,8-Indolizinetetrol, octahydro-, tetraacetate (ester), (1S,6S,7R,8R,8aR)- is not provided, but it may require specific conditions (e.g., temperature, pH, or solvent) to maintain its structure and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 79831-77-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,8,3 and 1 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 79831-77:
(7*7)+(6*9)+(5*8)+(4*3)+(3*1)+(2*7)+(1*7)=179
179 % 10 = 9
So 79831-77-9 is a valid CAS Registry Number.
79831-77-9Relevant academic research and scientific papers
Novel synthesis of castanospermine and 1-epicastanospermine
Cronin, Linda,Murphy, Paul V.
, p. 2691 - 2693 (2007/10/03)
(Chemical Equation Presented) Polyhydroxylated indolizidines have potential for treatment of HIV, hepatitis C and HSV infection, multiple sclerosis, angiogenesis, cancer, and diabetes. A new synthetic approach to the title compounds from a 5-C-methoxypyra
The Chemistry of Castanospermine, Part I: Synthetic Modifications at C-6
Furneaux, Richard H.,Gainsford, Graeme J.,Mason, Jennifer M.,Tyler, Peter C.
, p. 2131 - 2160 (2007/10/02)
Methodology for the selective functionalisation of castanospermine is outlined which has allowed the synthesis of a number of analogues selectively modified at C-6.Australine and some australine analugues have also been synthesized from castanospermine.
A concise, enantioselective synthesis of castanospermine
Kim,Choi,Cha
, p. 7096 - 7099 (2007/10/02)
A stereoselective synthesis of the polyhydroxy indolizidine alkaloids castanospermine (1) and 6,7-diepicastanospermine (4) has been achieved starting from the readily available alcohol 8. Subsequent Sharpless asymmetric epoxidation, followed by the azide displacement of the tosyl group gave the epoxy azide 12. The asymmetric dihydroxylation of 12 with (DHQ)2-PHAL gave tbe triol 13 in good diastereoselectivity. Alcohol protection, followed by reductive double cyclization of the resulting epoxy azide 17 gave 5-indolizidinone 18, which was then uneventfully converted to 1. On the other hand, the use of (DHQD)2-PHAL in the dihydroxylation of 12 provided a stereoselective preparation of 4.
Aromatization Reactions of Castanospermine Tetraacetate
Brown, Roger F. C.,Collins, David J.,Lagniton, Liana M.,Smith, Reginald J.,Wong, Neil R.
, p. 469 - 474 (2007/10/02)
The Polonovski Reaction of castanospermine tetraacetate N-oxide with acetic anhydride gave (+/-)-1-acetoxy-8-hydroxy-2,3-dihydro-1H-indolizinium acetate (10) by aromatization of the piperidine ring.N-Bromosuccinimide oxidation of castanospermine tetraacetate gave a low yield (4percent) of (+)-2-bromo-5,6,7,8-tetrahydroindolizine-6,7,8-triyl triacetate (13), by aromatization of the pyrrolidine ring.
