79848-49-0

Basic information

• Product Name: N^α-Boc-L-histidine trimethylsilyl ester
• Synonyms: N^α-Boc-L-histidine trimethylsilyl ester
• CAS NO: 79848-49-0
• Molecular Weight: 327.456
• Mol File: 79848-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-Boc-L-histidine trimethylsilyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-Boc-L-histidine trimethylsilyl ester(79848-49-0)
• EPA Substance Registry System: N^α-Boc-L-histidine trimethylsilyl ester(79848-49-0)

Safety Data

• Hazardous Substances Data: 79848-49-0(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 17791-52-5 N-(tert-butoxycarbonyl)-L-histidine 

Downstream Products

• 32926-43-5 N^α-(tert-butyloxy)carbonyl-N^im-triphenylmethyl-L-histidine 

Relevant articles and documents

IMPROVED METHODS OF OBTAINING Nim-TRITYL-SUBSTITUTED HISTIDINE DERIVATIVES

Two variants are proposed for the synthesis of Nα-Boc-Nim-tritylhistidiine.The first variant starts from Nα,Nim-di-Boc-histidine, from which the Nim-Boc group is removed with hydrazine hydrate.The Nα-Boc-histidine formed is esterified with chlorotrimethylsilane, tritylated in the imidazole group, and, after the elimination of the trimethylsilyl protection from the carboxyl group, Nα-Boc-Nim-tritylglycine is obtained with a yield of 80percent.The second variant starts from Nα,Nim-ditritylhistidine, which, by treatment with hydrochloric acid in acetone and then with dilute ammonia, is converted into Nim- tritylhistidine.From this, by acylation with di-tert-butyl pyrocarbonate, Nα-Boc-Nim-tritylhistidine is obtained with a yield of 91percent.The acylation of Nim-tritylhistidine with other alkoxycarbonylating reagents leads to Nα-tert-amyl-, Nα-benzyl-, and Nα-4-methoxybenzyloxycarbonyl derivatives of Nim-tritylhistidine.