798538-83-7Relevant academic research and scientific papers
Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor
Liang, Rui,Abrardo, Lauren,Brady, Edward J.,Candelore, Mari Rios,Ding, Victor,Saperstein, Richard,Tota, Laurie M.,Wright, Michael,Mock, Steve,Tamvakopolous, Constantin,Tong, Sharon,Zheng, Song,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.
, p. 587 - 592 (2007)
A series of conformationally constrained tri-substituted ureas were synthesized, and their potential as glucagon receptor antagonists was evaluated. This effort resulted in the identification of compound 4a, which had a binding IC50 of 4.0 nM a
GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
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, (2008/06/13)
Substituted aryl and heteroaryl derivatives are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
