798577-12-5Relevant academic research and scientific papers
Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates
Newhouse, Timothy R.,Kaib, Philip S. J.,Gross, Andrew W.,Corey
supporting information, p. 1591 - 1593 (2013/06/27)
A highly effective acid-catalyzed cyclopropyl ester to γ-lactone skeletal rearrangement has been demonstrated and applied to the synthesis of a variety of bi- and tricyclic functionalized lactones, rigid and highly compact structures for use as biological
Asymmetric allylic alkylation of ketone enolates: An asymmetric claisen surrogate
Burger, Erin C.,Tunge, Jon A.
, p. 4113 - 4115 (2007/10/03)
(Chemical Equation Presented) The combination of catalytic palladium(0) and Trost ligand provides an effective catalyst for the rearrangement of allyl β-ketoesters. The mechanism of the transformation involves formation of π-allyl palladium intermediates which undergo enantioselective attack by ketone enolates. Decarboxylation of β-ketocarboxylates allows regiospecific generation of enolates under extremely mild conditions.
On Baldwin's Kinetic Barrier Against 5-(Enol-endo)-exo-trigonal Closures: a Comparison of Ionic and Analogous Radical Reactions, and a New Synthesis of Cyclopentanones
Clive, Derrick L. J.,Cheshire, David R.
, p. 1520 - 1523 (2007/10/02)
The kinetic barrier that impedes ionic 5-(enol-endo)-exo-trigonal closures does not play such a dominant role in the case of α-oxo radicals (17); these radicals cyclize directly to cyclopentanones in a process that constitutes a synthetic method for conve
