133775-37-8

Upstream product

• 76644-52-5 rac-3-acetoxycyclohexene 
• 108-59-8 malonic acid dimethyl ester 
• 1521-51-3 rac-3-bromocyclohexene 
• 3413-44-3 (R)-2-cyclohexen-1-ol 
• 14032-04-3 trans-2-phenylthiocyclohexanol 
• 10039-14-2 2-iodo-1-cyclohexanol 
• 14447-34-8 (+)-(R)-cyclohex-2-en-1-yl acetate 
• 133775-38-9 (1R, 2R)-2-(phenylthio)cyclohexyl acetate 
• 110-83-8 cyclohexene 
• 125627-30-7 S-isopropyl 2-((1R)-cyclohex-2-enyl)thioacetate 
• 133715-22-7 ethyl (R)-2-cyclohexenylacetate 
• 161266-94-0 (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl (1R)-2-(cyclohex-2-ene)acetate 

Downstream Products

• 133775-35-6 (R)-(2-cyclohexen-1-yl)acetyl chloride 
• 798577-12-5 (R)-1-Cyclohex-2-enyl-propan-2-one 
• 133715-11-4 ((3aR,11R,11aR,11bS)-9-Benzyloxy-5-oxo-1,2,3,3a,4,5,10,11,11a,11b-decahydro-5a-aza-benzo[cd]fluoranthen-11-yl)-carbamic acid benzyl ester 
• 133715-24-9 (R) p-Methoxybenzyl (E)-3-[4-benzyloxy-1-(2-cyclohexen-1-yl)acetyl-1H-indol-3-yl]propenoate 
• 1027905-47-0 (3aR,11R,11aR,11bS)-9-Benzyloxy-5-oxo-1,2,3,3a,4,5,10,11,11a,11b-decahydro-5a-aza-benzo[cd]fluoranthene-11-carbonyl azide 
• 133715-10-3 (3aR,11R,11aR,11bS)-9-Benzyloxy-5-oxo-1,2,3,3a,4,5,10,11,11a,11b-decahydro-5a-aza-benzo[cd]fluoranthene-11-carboxylic acid 
• 133775-36-7 <3aR-(3aα,12α,12aα,12bα)>-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydroxyisoquino<2,1,8-lma>carbazol-2(1H)-one hydrochloride 

Relevant academic research and scientific papers

Asymmetric Catalysis by Vitamin B12: The Isomerization of Achiral Cyclopropanes to Optically Active Olefins

Achiral spiroactivated cyclopropanes are isomerized to optically active (R)-(cycloalk-2-enyl)-Meldrum's acids (= (R)-5-(cycloalk-2-enyl)-2,2-dimethyl-1,3-dioxane-4,6-diones) in high yield and ee's up to 86percent by catalytic amounts of cob(I)alamin in po

A highly stereoselective divergent synthesis of bicyclic models of photoreactive sesquiterpene lactones

Sesquiterpene lactones are natural stereochemically pure compounds, which show a number of biological activities. In order to study the reactivity of sesquiterpene lactones in biological systems, we describe herein the asymmetric synthesis of a simple mod

Investigation of the Chemo- and Stereoselectivity of the Ketene-Claisen Rearrangement

A novel type of ketene-Claisen rearrangement in which the precursor of the rearrangement is generated in situ by reaction of optically active allyl thioethers with dichloroketene is described. A characteristic feature of this rearrangement is the excellen

Synthesis of an enantiomerically pure aminoisoquinocarbazole with antiarrhythmic activity via lipase-catalyzed enantioselective transesterification

Enantiomerically pure (R)-2-cyclohexen-1-ol 5 was prepared via lipase- catalyzed enantioselective transesterification of 2-substituted cyclohexanol, and stereospecifically converted to (-)-(2-cyclohexenyl)acetic acid 4. Enantiomerically pure aminoisoquinocarbazole 1 (RS-2135) was synthesized stereoselectively from 4, using an intramolecular Diels-Alder reaction and Curtius rearrangement.

A simple preparation of (R)-(2-cyclopentenyl)acetic acid and (R)-(2-cyclohexenyl)acetic acid using β-diastereoselective radical cyclization in the presence of Lewis acid

The alkenyl radical generated from (-)-8-phenylmenthyl 7-iodo-2,6-heptadienoate smoothly cyclized to afford (R)-(2-cyclopentenyl)acetate with 88% de in 90% yield. (R)-(2-Cyclohexenyl)acetate was also obtained with 84% de in 72% yield under the same conditions. The presence of Lewis acid is essential for high diastereoselectivity and chemical yield.

Indolobenzoquinoline derivatives, their preparation and their use as anti-arrhythmic drugs

Optically active compounds of formula (I): in which R1 is hydrogen or alkyl; Xband Ybare hydrogen or hydroxy; and Z is -NRaRb, in which Raand Rbare hydrogen, alkyl or hydroxyalkyl,or a cyclic amino group;, and pharmaceutically acceptable salts thereof have enhanced anti-arrhythmic activity and may be prepared by a stereospecific synthesis process.