79917-89-8

Usage

Uses

Used in Pharmaceutical Industry:
1H-imidazole, 2,3-dihydro-1-methyl-3-propyl-, hydrochloride (1:1) is used as a pharmaceutical intermediate for the development of drugs targeting the central nervous system. Its unique structure and properties allow it to interact with specific receptors and pathways, making it a promising candidate for the treatment of various neurological disorders.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-imidazole, 2,3-dihydro-1-methyl-3-propyl-, hydrochloride (1:1) serves as a building block for the production of a variety of chemical compounds. Its versatility and reactivity make it an essential component in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Drug Solubility and Stability Enhancement:
The hydrochloride form of 1H-imidazole, 2,3-dihydro-1-methyl-3-propylenhances the solubility and stability of the compound, which is crucial for the development of pharmaceuticals. Improved solubility facilitates better absorption and bioavailability, while enhanced stability ensures the compound's effectiveness over time, making it a valuable tool in drug formulation and development.

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 540-54-5 1-Chloropropane 

Downstream Products

• 74-89-5 methylamine 
• 64-18-6 formic acid 
• 1018813-43-8 [1-propyl-3-methylimidazolium][Cd(1,3,5-benzenetricarboxylate)] 
• 1331734-74-7 1-methyl-3-propylimidazolium O,Se-dimethylphosphoroselenoate 
• 1331734-63-4 1-methyl-3-propylimidazolium O,S-dimethylphosphorothioate 
• 1060693-29-9 1-methyl-3-propylimidazol-3-ium hydroxide 

Relevant academic research and scientific papers

A simple study on vaporization enthalpy of taurine anion-based ionic liquid

Room temperature ionic liquids, as a new type of environmentally friendly “green solvents”, have many well-known and unique properties, which lay the foundation for their wide application in many fields. Two target products, 1-propyl-3-methylimidazolium taurine ionic liquid and 1- butyl ?3- methylimidazolium taurine ionic liquid, were synthesized by conventional two - step synthesis method. Hydrogen and carbon NMR spectra were also used to verify the chemical structure of the target products. Isothermal thermogravimetric analysis was used to record the decreasing trend of the weight for two ionic liquids samples over time. According to Langmuir equation and Clausius-Clapeyron equation, vaporization enthalpies of two ionic liquids were obtained. For the study of thermodynamic properties, the vaporization enthalpy data of ionic liquid in a certain temperature range are very important and indispensable.

1 - Methyl -3 - propyl imidazole taurine ionic liquid as well as preparation method and application thereof

The invention discloses a 1-methyl-3-propyl imidazole taurine ionic liquid as well as a preparation method and application thereof. The preparation method disclosed by the invention belongs to a two-step synthesis method and comprises the following steps: firstly carrying out pretreatment and prepurification on raw materials, then transforming 1-methyl-3-propyl imidazole chlorine salt into an oxyhydrogen type intermediate by virtue of anion exchange resin, and then mixing taurine with an oxyhydrogen type substance, so that a final product is obtained. The preparation method has the advantage that the prepared product has high purity. A byproduct in a reaction process is mainly water and can be removed by means of vacuum drying. The 1-methyl-3-propyl imidazole taurine ionic liquid product can be used for absorbing gas such as CO2 and SO2.

Preparation of nanocellulose using ionic liquids: 1-propyl-3-methylimidazolium chloride and 1-ethyl-3-methylimidazolium chloride

Cellulose nanocrystals were prepared using ionic liquids (ILs), 1-ethyl-3-methylimidazolium chloride [EMIM][Cl] and 1-propyl-3-methylimidazolium chloride [PMIM][Cl], from microcrystalline cellulose. The resultant samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The XRD results showed that nanocellulose obtained by treatment with both ILs preserved basic cellulose I structure, but crystallinity index of samples (except for Sigmacell treated with [EMIM][Cl]) was lower in comparison to the starting microcrystalline cellulose. The DLS results indicated noticeably smaller particle sizes of prepared cellulose for material treated with [PMIM][Cl] compared to cellulose samples hydrolyzed with [EMIM][Cl], which were prone to agglomeration. The obtained nanocellulose had a rod-like structure that was confirmed by electron microscopy analyses. Moreover, the results described in this paper indicate that cation type of ILs influences particle size and morphology of cellulose after treatment with ionic liquids.

Europium metal-organic frameworks as recyclable and selective turn-off fluorescent sensors for aniline detection

Seven Eu-(H)BDC compounds, [RMI][Eu2(BDC)3Cl] (R = ethyl (1), propyl (2), butyl (3), H2BDC = 1,4-benzenedicarboxylic acid), [EMI]2[Eu2(BDC)3(H2BDC)Cl2] (4), [Eu(BDC)(HCOO)] (5), [Eu(BDC)Cl(H2O)] (6) and [Eu3(BDC)4Cl(H2O)6] (7), were synthesized under ionothermal conditions. Compounds 4 and 6 behave as potential highly selective turn-off fluorescent sensors for aniline, which can be detected in mixtures of aniline with contrast organic amides or alkylbenzenes. Fluorescence quenching can be observed when compounds 4 and 6 mix with the samples containing aniline. Compounds 4 and 6 show basically unchanged emission intensities and rapid response to aniline after ten recycling tests, suggesting that the compounds have high stable recycle repeatabilities.

Ionothermal synthesis, structures, properties of cobalt-1,4-benzenedicarboxylate metal-organic frameworks

Eight kinds of 1-methyl-3-alkylimidazolium halide [RMI]X (R=ethyl (E), propyl (P), butyl (B) and amyl (A); MI = imidazolium; X= Cl-, I-) ionic liquids (ILs) were used as reaction media and obtained a series of 2D [RMI]2[Co3(BDC)3X2] frameworks through the ionothermal reactions of 1,4-benzenedicarboxylic acid (H2BDC) with Co(NO3)2·6H2O. The 2D [RMI]2[Co3(BDC)3X2] frameworks exhibit a same (3,6) topology network with [RMI]+ cations locating in the interlayer space. [RMI]+ cations play a template role in the structure constructions, whose influence combining with the effect of X- anions pass to the TG behaviors. The decomposition temperatures of the [RMI]2[Co3(BDC)3X2] frameworks decrease with the alkyl chains in [RMI]+ cations, and the compounds containing Cl- show higher thermal stabilities than those with I-. However, compounds 1-8 exhibit two similar broad emissions at ca. 380 and 390 nm, assigned to ILCT. The RMI+ templates and the X- anions do not exert their influence on the fluorescence.

Combination effect of ionic liquid components on the structure and properties in 1,4-benzenedicarboxylate based zinc metal-organic frameworks

Two types of 2D [RMI]2[Zn3(BDC)3X2] (Type A) and 3D [Zn(BDC)(H2O)] (Type B) (H2BDC = 1,4-benzenedicarboxylate acid) compounds were synthesized with three kinds of 1-alkyl-3-methyl imidazolium halide ([RMI]X) ionic liquids. Type A is the primary structure model showing a (3,6) network. Type B can be obtained from [BMI]Cl, [AMI]Cl and [AMI]Br media, showing a 4,4-connected {42·84} network. The structure, TG, and fluorescence analyses demonstrate the combination effect of the RMI+ templating effect and X- controlling the structure types. The boundary between Types A and B is from [PMI]Cl, via [BMI]Br, to [AMI]I as the reaction media. The decomposition temperatures of the compounds in Type A decrease with increased RMI+, while X- anions exert the influence that compounds containing Br- supply the highest thermal stability. Similarly, with increased RMI+, or X = I-, the compounds show red shifts compared to the emissions of the ligand.

Synthesis, characterization and thermal properties of thiosalicylate ionic liquids

In an attempt to produce new functionalized ionic liquids, a series of thiosalicylate ionic liquids based on imidazolium, ammonium, phosphonium, choline and pyrrolidinium cations were synthesized. The compounds were characterized by Infra Red (IR), Nuclear Magnetic Resonance (NMR) and mass spectra (ESI-MS). Their glass-transition temperatures, melting points and decomposition temperatures have been measured. Physicochemical properties of ionic liquids are influenced by alkyl chain length and nature of the cation of ionic liquids. Indian Academy of Sciences.

Synthesis, structure, and physico-optical properties of manganate(II)-based ionic liquids

Several ionic liquids (ILs) based on complex manganate(II) anions with chloro, bromo, and bis(trifluoromethanesulfonyl)amido (Tf2N) ligands have been synthesized. As counterions, n-alkyl-methylimidazolium (C nmin) cations of different chain length (alkyl = ethyl (C 2), propyl (C3), butyl (C4), hexyl (C 6)) were chosen. Except for the 1-hexyl-3-methylimidazolium ILs, all of the prepared compounds could be obtained in a crystalline state at room temperature. However, each of the compounds displayed a strong tendency to form a supercooled liquid. Generally, solidification via a glass transition took place below -40°C. Consequently, all of these compounds can be regarded as ionic liquids. Depending on the local coordination environment of Mn 2+, green (tetrahedrally coordinated Mn2+) or red (octahedrally coordinated Mn2+) luminescence emission from the 4T(G) level is observed.[1] The local coordination of the luminescent Mn2+ centre has been unequivocally established by UV/Vis as well as Raman and IR vibrational spectroscopies. Emission decay times measured at room temperature in the solid state (crystalline or powder) were generally a few ms, although, depending on the ligand, values of up to 25 ms were obtained. For the bromo compounds, the luminescence decay times proved to be almost independent of the physical state and the temperature. However, for the chloro- and bis(trifluoromethanesulfonyl)amido ILs, the emission decay times were found to be dependent on the temperature even in the solid state, indicating that the measured values are strongly influenced by nuclear motion and the vibration of the atoms. In the liquid state, the luminescence of tetrahedrally coordinated Mn2+ could only be observed when the tetrachloromanganate ILs were diluted with the respective halide ILs. However, for [C3mim][Mn(Tf2N)3], in which Mn 2+ is in an octahedral coordination environment, a weak red emission from the pure compound was found even in the liquid state at elevated temperatures.

Influence of different branched alkyl side chains on the properties of imidazolium-based ionic liquids

Several new branched ionic liquids were synthesized under microwave irradiation applying two different synthetic approaches. Different already known ionic liquids, both linear and branched, were added to this set of new ionic liquids to investigate the influence of the branching on the thermophysical properties to elucidate first structure-property relationships. Thermogravimetric analysis was utilized to investigate the decomposition behavior and differential scanning calorimetry was used to study the influence of the branching on the thermal behavior, e.g. the melting point, the glass transition temperature, the freezing point and the cold crystallization temperature. Moreover, the water uptake of selected ionic liquids was analyzed. The Royal Society of Chemistry 2008.

Lonization state and ion migration mechanism of room temperature molten dialkylimidazolium fluorohydrogenates

The ionization state of room temperature molten salts, alkylimidazolium fluorohydrogenates (RMIm-(HF)2.3F: R = alkyl group, M =methyl group), was evaluated from the observed diffusion coefficient and viscosity, using the Stokes-Einstein relation. Assuming that the dissociation degree of the salt is acceptable for representation of the ionic state of the molten salts, the larger the cation size with elongation of the alkyl chain was, the higher the dissociation degree of the salt Further, we proposed that an idea of the "degree of ordering of cations and anions" was more suitable to represent the ionization state without solvent species. On the basis of this idea, the smaller the cation size of RMIm(HF)2.3F salt was, the higher the ordering of the ion, indicating formation of domain particles of aggregated ions as a unit of mobile species such as A(AX)m + and X(AX)n- for A+X- salt. It was found that highly ordered particles, with large numbers for m and n, showed a high diffusion coefficient. ? 2005 American Chemical Society.