799280-24-3

Basic information

• Product Name: 2-hydroxy-5-(2-methyl-thiazol-5-yl)-benzamide
• Synonyms: 2-hydroxy-5-(2-methyl-thiazol-5-yl)-benzamide
• CAS NO: 799280-24-3
• Molecular Weight: 234.279
• Mol File: 799280-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-5-(2-methyl-thiazol-5-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-5-(2-methyl-thiazol-5-yl)-benzamide(799280-24-3)
• EPA Substance Registry System: 2-hydroxy-5-(2-methyl-thiazol-5-yl)-benzamide(799280-24-3)

Safety Data

• Hazardous Substances Data: 799280-24-3(Hazardous Substances Data)

Upstream product

• 40187-51-7 5-acetylsalicylamide 
• 73866-23-6 5-(2-bromoacetyl)-2-hydroxybenzamide 
• 62-55-5 thioacetamide 

Relevant articles and documents

Synthesis of some new 5-(2-substituted-1,3-thiazol-5-yl)-2-hydroxy benzamides and their 2-alkoxy derivatives as possible antifungal agents

The 2-hydroxy-5-(1,3-thiazol-5-yl) benzamide (4a), 5-(2-amino-1, 3-thiazol-5-yl)-2-hydroxy benzamide (4b), 2-hydroxy-5-(2-alkyl-1,3-Thiazol-5-yl) benzamide (4c and 4d), 5-{2-[(N-substituted aryl)amino]-1,3-thiazol-5-yl}2- hydroxy benzamides (6a-j) were prepared by reacting 5-(bromoacetyl) salicylamide (2) with thiourea, thioformamide, thioalkylamide (3c-d) and substituted thioureas (5a-j) in absolute ethanol. These compounds were converted to 5-(2-substituted-1,3-thiazol-5-yl)-2-alkoxybenzamides and 5-(2-N-(substituted aryl)-1,3-thiazol-5-yl)-2-alkoxy benzamides (8a-g) by reacting with n-alkylbromides (7a-b) in presence of a base. The newly synthesized compounds were characterized by IR, 1H-NMR and mass spectral data. Compounds were also screened for their antifungal activity.