79932-24-4Relevant academic research and scientific papers
1-Oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides
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, (2008/06/13)
Antiallergy and antiulcer agents having the formula (I), STR1 and their pharmaceutically acceptable salts, wherein R1 and R2 taken separately are each hydrogen or lower alkyl; and R1 and R2 taken together are alkylene of 3-9 carbon atoms or phenylalkylene of 9-11 carbon atoms, with the proviso that the ring so formed is between 5- and 8-membered; acids of the formula (II), STR2 wherein R1 and R2 are as defined above and R3 is hydrogen, which are useful as intermediates for compounds of the formula (I), but in many instances also possess the same useful biological activity as do formula I compounds; and intermediates of the formula II wherein R1 and R2 are defined as above, and R3 is alkyl of 1 to 4 carbon atoms, carbalkoxy of 2 to 5 carbon atoms, carbophenoxy or carbobenzoxy, are also described.
Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
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, (2008/06/13)
This invention encompasses orally effective antiulcer agents of the formula STR1 wherein X is hydroxy, (C1 -C5)-alkoxy, phenoxy, benzyloxy, or --NH(CH2)n Y wherein n is an integer of value 2 to 4 and Y is di-(C1 -C3)-alkylamino, 1-pyrrolidinyl, 1-piperidinyl or 4-morpholinyl; R' and R" when taken together are (C3 -C8)-alkylene, with the proviso that the ring so formed is 5- to 8-membered; R' and R" when taken separately are each independently hydrogen, (C1 -C6)-alkyl or (C5 -C6)-cycloalkyl, with the proviso that when X is other than --NH(CH2)n Y, at least one of R' and R" is other than hydrogen; the pharmaceutically acceptable cationic salts thereof when X is hydroxyl, and the pharmaceutically acceptable anionic salts thereof when X is --NH(CH2)n Y.
