79944-56-2 Usage
Uses
Used in Pharmaceutical Research:
Idazoxan hydrochloride is used as a research tool for studying the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems. Its ability to selectively target α2-receptors aids in understanding the complex interactions within the brain and the potential for developing novel therapeutic agents.
Used in Neurological Applications:
In the field of neurology, Idazoxan hydrochloride is used as an antiparkinsonian agent, specifically as an Alpha2 agonist. This application leverages its receptor selectivity to help manage the symptoms associated with Parkinson's disease, providing a targeted approach to treatment.
Used in Preclinical Studies:
Idazoxan hydrochloride is utilized in preclinical studies involving rat brain research, where it serves as a pure antagonist. Its selectivity for α2over α1-receptors makes it a valuable compound for investigating the roles and interactions of these receptors in various physiological and pathological processes.
Biological Activity
α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
Check Digit Verification of cas no
The CAS Registry Mumber 79944-56-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,9,4 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 79944-56:
(7*7)+(6*9)+(5*9)+(4*4)+(3*4)+(2*5)+(1*6)=192
192 % 10 = 2
So 79944-56-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
79944-56-2Relevant academic research and scientific papers
Pharmaceutical composition based on idazoxan, salts, hydrates or polymorphs thereof
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Page/Page column 8; 9, (2008/06/13)
Pharmaceutical composition comprising 5 to 20% of an idazoxan salt or of idazoxan hydrate, 10 to 40% of microcrystalline cellulose, 1 to 5% of lubricant, 0.1 to 0.5% of colloidal silica and from 29.5% to 84.8% of lactose, with respect to the total mass.
Benzodioxane-imidazoline compounds as antihypertensives
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, (2008/06/13)
Compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein: n is an integer equal to 0, 1, 2 or 3; R1 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenyl lower alkyl; each R is independently hydrogen, lower alkyl, optionally substituted phenyl, or optionally substituted phenyl lower alkyl; are α2 blockers, and, therefore, are useful in treating essential hypertension and depression, and in inhibiting platelet aggregation.
2--2-IMIDAZOLINE HYDROCHLORIDE
Chapleo, Christopher B.,Myers, Peter L.
, p. 4839 - 4842 (2007/10/02)
A new synthesis of 2--2-imidazoline hydrochloride from 2-cyano-benzodioxan is described and the previously claimed route to this compound is shown to give a formula isomer, ie. 2-methyl-2--2-imidazoline hydrochloride.
