799560-21-7

Basic information

• Product Name: Carbamic acid, [(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-(phenylsulfonyl)propyl]-, 1,1-dimethylethyl ester
• CAS NO: 799560-21-7
• Molecular Formula: C21H27NO5S
• Molecular Weight: 405.515
• Mol File: 799560-21-7.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-(phenylsulfonyl)propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-(phenylsulfonyl)propyl]-, 1,1-dimethylethyl ester(799560-21-7)
• EPA Substance Registry System: Carbamic acid, [(1S,2S)-2-hydroxy-1-(phenylmethyl)-3-(phenylsulfonyl)propyl]-, 1,1-dimethylethyl ester(799560-21-7)

Safety Data

• Hazardous Substances Data: 799560-21-7(Hazardous Substances Data)

Upstream product

• 3112-85-4 methylphenylsulfonate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 169701-71-7 (3S)-3-(tert-butoxycarbonylamino)-4-phenyl-1-(phenylsulfonyl)-2-butanone 
• 149451-80-9 (2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol 
• 116949-67-8 (2S,3S)-2-azido-1-phenyl-butane-3,4-diol 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 
• 78571-81-0 (R,R)-3-(phenylmethyl)oxiranemethanol 
• 42238-15-3 (2E)-4-phenylbut-2-en-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 153864-55-2 (2S,3S)-3-(tert-butoxycarbonylamino)-4-phenyl-1-phenylthio-2-butanol 

Downstream Products

• 799560-42-2 (3S,E)-3-(tert-butoxycarbonylamino)-4-phenyl-1-phenylsulfonyl-1-butene 

Relevant articles and documents

Synthesis of chiral, enantiopure allylic amines by the Julia olefination of α-amino esters

The four-step conversion of a series of N-Boc-protected L-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild conditions, with good yields, and without loss of stereochemical integrity, being in this respect superior to the conventional Julia reaction of α-amino aldehydes.

Enantiodivergent, catalytic asymmetric synthesis of γ-amino vinyl sulfones

A set of diversely substituted N-Boc-γ-amino vinyl sulfones has been prepared by a four-step procedure from readily available, highly enantiopure anti-N-Boc-3-amino-1,2-alkanediols. This new route, which does not depend on the accessibility of α-amino acids as starting materials, is noteworthy for its efficiency, for its generality, and for the fact that both enantiomers of a given γ-amino vinyl sulfone can be obtained with equal ease.