79982-56-2

Usage

Uses

Used in Organic Synthesis:
Osmium bis(2,2'-bipyridine)chloride is used as a catalyst for the oxidation of organic compounds, facilitating the conversion of substrates into desired products with improved efficiency and selectivity.
Used in Chemical Reactions:
osmium bis(2,2'-bipyridine)chloride is employed as a catalyst in a variety of chemical reactions, enhancing the reaction rates and improving the overall yield of the target products.
Used in Industrial Processes:
Osmium bis(2,2'-bipyridine)chloride is utilized in various industrial processes, where its high stability and low toxicity make it an advantageous catalyst for large-scale applications.
Used in Research and Development:
In the field of research and development, osmium bis(2,2'-bipyridine)chloride is used to explore new reaction pathways and develop innovative synthetic methods, contributing to the advancement of chemical science and technology.

Upstream product

• 366-18-7 [2,2]bipyridinyl 
• 13444-93-4 osmium(III) chloride 
• 1307-81-9 Na₂OsCl₆*xH₂O 
• 98783-94-9 bipyH{OsbipyCl₄} 
• 64122-67-4 2,2'-bipyridyl monohydrate 
• 57288-05-8 [Os(2,2'-bypiridine)Cl₄] 
• 15699-65-7 {Os(bis(2,2'-bipyridine))Cl₂}Cl 

Downstream Products

• 848344-90-1 osmium dibipyridyl t-Boc histamine 
• 23648-06-8 tris(2,2'-bipyridine)osmium(II) 
• 91190-06-6 {bis(2,2'-bipyridyl)(4,4'-bipyridyl)(chloro)osmium} hexafluorophosphate 
• 135774-17-3 {Os(2,2'-bipyridine)2(2,2'-bis(2-pyridyl)bibenzimidazole)Os(2,2'-bipyridine)2}(ClO₄)4*6H₂O 
• 122904-99-8 [Os(2,2'-bipyridine)2(2,3-bis(2-pyridyl)pyrazine)]⁽²⁺⁾ 
• 478083-40-8 Osbipy₂C₂O₄*H₂O 

Relevant academic research and scientific papers

Sensor array system for discrimination and detection for reactive chemical species comprising fluorescence compounds

The present invention relates to a sensor array system comprising a fluorescent compound for discrimination and detection of active species. 2 Or more compounds according to one aspect, hydrates, solvates or salts thereof, compositions for detecting active species including the same, sensor arrays, or methods of detecting active species using the same are capable of selectively distinguishing various active species. The present invention relates to a composition for detecting an active species, a method for detecting an active species, and a method for detecting an active species.

Physical, spectroscopic, and biological properties of ruthenium and osmium photosensitizers bearing diversely substituted 4,4′-di(styryl)-2,2′-bipyridine ligands

Capitalising on the previous identification of a distyryl coordinated Ru(ii) polypyridine complex as a promising photosensitizer for photodynamic therapy, eight new complexes were synthesized by modifications of the ligands or by changing the metal coordinated. We report in this work the effects of these modifications on the physical, spectroscopic, and biological properties of the synthesized complexes. Subtle structural modifications of the distyryl ligand only had a moderate effect on the corresponding complexes' visible light absorption and singlet oxygen quantum yield. These modifications however had a significant effect on the lipophilicity, the cellular uptake and the phototoxicity of the complexes. Although the lipophilicity of the complexes had a somewhat expected effect on their cellular uptake, this last parameter could not be directly correlated to their phototoxicity, revealing other underlying phenomena. Overall, this work allowed identification of two promising ruthenium complexes as photosensitisers for photodynamic therapy and provides some guidance on how to design better photosensitizers. This journal is

Osmium complex as well as preparation method and application thereof

The invention relates to an osmium complex as well as a preparation method and application thereof. The method comprises the following steps: adding ammonium chlorosmate and dipyridine into an organicsolvent, and performing a reaction so as to obtain a mixed solution; adding a reducing agent into the mixed solution, and performing a reaction so as to obtain an osmium complex precursor; and addingthe osmium complex precursor and 5-chlorine-2-benzodiazopyridine into ethylene glycol according to a preset ratio, performing a reaction under predetermined reaction conditions, and adding target anion, so as to obtain the osmium complex. The osmium complex provided by the invention has extremely high structural stability, barely emits fluorescence, has strong cytotoxicity to tumor cells, has selectivity to cancer cells, and can be applied in the field of Raman imaging of tumor cells.

A NIR phosphorescent osmium(ii) complex as a lysosome tracking reagent and photodynamic therapeutic agent

A novel near infrared (NIR) phosphorescent osmium complex (Os1) was developed for lysosome tracking and photodynamic therapy. Owing to its NIR photophysical properties, cellular imaging ability and phototoxicity, it has advantages over its ruthenium analogue (Ru1).

One type of dual-wavelength emission, double-heteronuclear metal complex and its preparation method and application

The invention provides a double-wavelength emitting heterobinuclear metal complex as well as a preparation method and application thereof. The heterobinuclear metal complex has the structural general formula: (L1L2)M-L3-M'(L4L5)Ym, wherein M and M' are respectively and independently selected from Ru, Os, Ir and Re, but, M and M' cannot be the same metal at the same time. The heterobinuclear metal complex can be used as an electrogenerated chemiluminescent substance, and the heterobinuclear metal complex or the heterobinuclear metal complex and amines are used as a co-reactant, so that single-wavelength ECL detection can be realized under respective emitting wavelengths, and proportional ECL detection can also be realized under double emitting wavelengths. Particularly, when one of M and M' is Ir, the heterobinuclear metal complex can only be used for specifically dyeing RNA (Ribonucleic Acid), and the heterobinuclear metal complex is remarkably enhanced in fluorescence after being dyed and can be used for RNA nature determination, quantitative detection and relevant fields such as nucleic acid marking, clinic medical diagnosis, blood cell analysis, immunoassay detection and cancer therapy.

Water-Soluble Osmium Complexes Suitable for use in Luminescence-Based, Hydrogel-Supported Sensors

Osmium transition metal complexes are of particular interest in luminescence-based sensing applications because of their longer wavelength absorptions and emissions, relative to similar ruthenium and rhenium complexes, that allow for inexpensive excitation and minimize interferences from autofluorescence when the sensor is used in biological samples. Reported here are the photophysical properties of a series of water-soluble osmium complexes suitable for use in hydrogel-based sensors: [Os(bpy)2(sulf-dpp)]Cl2, [Os(phen)2(sulf-dpp)]Cl2, [Os(dpp)2(sulf-dpp)]Cl2, and [Os(CO)2Cl2(sulf-dpp)], where bpy is 2,2′-bipyridine, phen is 1,10-phenanthroline, dpp is 4,7-diphenyl-1,10-phenanthroline, and sulf-dpp is bathophenanthrolinedisulfonic acid disodium salt. The family of complexes showed minimal oxygen quenching, making them particularly well-suited for sensing applications in which oxygen concentration varies. Luminescence anisotropy was found to depend more significantly on net dipole moment than hydrodynamic radius of the molecule, and, as expected, excited state lifetime and luminescence anisotropy were highly dependent on the local environment of the reporter molecule. Results obtained for hydrogel-based relative humidity sensors containing [Os(CO)2Cl2(sulf-dpp)] and [Os(bpy)2(sulf-dpp)]Cl2 complexes highlight the significant potential for this class of compounds in a hydrogel-supported luminescence-based sensing approach.

Toward the Control of the Creation of Mixed Monolayers on Glassy Carbon Surfaces by Amine Oxidation

A versatile and simple methodology for the creation of mixed monolayers on glassy carbon (GC) surfaces was developed, using an osmium-bipyridyl complex and anthraquinone as model redox probes. The work consisted in the electrochemical grafting on GC of a mixture of mono-protected diamine linkers in varying ratios which, after attachment to the surface, allowed orthogonal deprotection. After optimisation of the deprotection conditions, it was possible to remove one of the protecting groups selectively, couple a suitable osmium complex and cap the residual free amines. The removal of the second protecting group allowed the coupling of anthraquinone. The characterisation of the resulting surfaces by cyclic voltammetry showed the variation of the surface coverage of the two redox centres in relation to the initial ratio of the linking amine in solution.

Osmium(II) polypyridyl polyarginine conjugate as a probe for live cell imaging; A comparison of uptake, localization and cytotoxicity with its ruthenium(II) analogue

A first investigation into the application of a luminescent osmium(II) bipyridine complex to live cell imaging is presented. Osmium(II) (bis-2,2-bipyridyl)-2(4-carboxylphenyl) imidazo[4,5f][1,10]phenanthroline was prepared and conjugated to octaarginine, a cell penetrating peptide. The photophysics, cell uptake and cytotoxicity of this osmium complex conjugate were performed and compared with its ruthenium analogue. Cell uptake and distribution of both ruthenium and osmium conjugates were very similar with rapid transmembrane transport of the osmium probe (complete within approx. 20 min) and dispersion throughout the cytoplasm and organelles. The near-infrared (NIR) emission of the osmium complex (λmax 726 nm) coincides well with the biological optical window and this facilitated luminescent and luminescence lifetime imaging of the cell which was well resolved from cell autofluorescence. The large Stokes shift of the emission also permitted resonance Raman mapping of the dye within CHO cells. Rather surprisingly, the osmium conjugate exhibited very low cytotoxicity when incubated both in the dark and under visible irradiation. This was attributed to the remarkable stability of this complex which was reflected by the complete absence of photo-bleaching of the complex even under extended continuous irradiation. In addition, when compared to its ruthenium analogue its luminescence was short-lived in water therefore rendering it insensitive to O2.

Preparation of fluorescent tubulin binders

Thiocolchicine, taxol and cephalomannine have been used as building blocks for the preparation of four different fluorescent compounds designed to image the tubulin/microtubule network in cells. Thiocolchicine gave the best results and, in particular, the compound derived from conjugation with fluorescein minimally inhibits tubulin polymerization, is cell permeable and binds microtubules. Thus, it meets some of the demanding requirements for a new fluorescent dye that can secure a direct assay to evidence the tubulin/microtubules network in cells.

Osmium bipyridine-containing redox polymers based on cellulose and their reversible redox activity

Thermo-, pH-, and electrochemical-sensitive cellulose graft copolymers, hydroxypropyl cellulose-g-poly(4-vinylpyridine)-Os(bipyridine) (HPC-g-P4VP-Os(bpy)), were synthesized and characterized. The electrochemical properties of the resulting material were investigated via cyclic voltammetry by coating the graft copolymers on the platinized carbon electrode. The results indicated that the electrochemical properties of the graft copolymer modified electrode were responsive to the pH values of the electrolyte solution. The reversible transformation between the active and inactive state originated from the changes in the architecture of the HPC-g-P4VP-Os(bpy) graft copolymer at different pH values. At high pH (e.g., above the pKa of P4VP), the chains of P4VP collapsed, and the electrochemical activity of the electrode was reduced. With immobilization of glucose oxidase (GOx) on the graft copolymer decorated electrode, a biosensor for glucose detection was prepared. The current of the biosensor depended on the glucose concentration in the detected solution and increased with the successive addition of glucose.