799835-40-8

Usage

Structure

A pyrazole ring with an iodine atom and a methyl group attached

Aromatic ring

Five-membered with two nitrogen atoms

Unique chemical properties

Due to the presence of the iodine atom and the methyl group

Uses in research

Commonly used in organic synthesis and drug discovery

Potential pharmacological activities

May have antifungal, antibacterial, and anti-inflammatory properties

Industrial applications

Can be used as an intermediate in the production of pharmaceuticals and agrochemicals.

Upstream product

• 799835-39-5 ethyl 3-iodo-1-methyl-1H-pyrazole-4-carboxylate 
• 21230-43-3 3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS

Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF

The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.

A Michael Equilibration Model to Control Site Selectivity in the Condensation toward Aminopyrazoles

A Michael equilibration model is presented to provide for site-selective pyrazole condensations between alkoxyacrylonitriles and hydrazines. Both pyrazole isomers were accessed with high selectivity by employment of kinetically or thermodynamically controlled conditions. Substrate scope and identification of Michael intermediates, as well as competitive pathways, support the presented mechanistic proposal. Sandmeyer derivatization provided site-selective access to fully substituted pyrazoles.

Iodopyrazolyl carboxanilides

This invention relates to novel iodopyrazolylcarboxanilides of the formula (I) t,0010 in which R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, to a plurality of processes for preparing these compounds and to their use for controlling unwanted microorganisms. This invention further relates to novel intermediates and their preparation.

IODOPYRAZOLYL CARBOXANILIDES

The invention relates to iodopyrazolyl carboxanilides of formula (I), in which R1, R2, R3, R4, R5, R6 and Z are defined as cited in the description. The invention also relates to several methods for producing said substances and to the use of the latter for controlling undesired micro-organisms, in addition to novel intermediate products and their production.

Pyrazole carboxanilide fungicides and use

Novel N-[2-(cyclic alkyl)phenyl]pyrazole-4-carboxamides useful as fungicides, methods of using said compounds, and fungicidal compositions containing them.