799835-39-5

Upstream product

• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 21230-43-3 3-amino-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 110-46-3 isopentyl nitrite 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 

Downstream Products

• 116344-31-1 ethyl 1-methyl-3-phenyl-1H-pyrazole-4-carboxylate 
• 105994-56-7 1-methyl-3-phenyl-1H-pyrazole-4-carboxylic acid 
• 799835-40-8 3-iodo-1-methyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

INHIBITORS OF RIP1 KINASE AND METHODS OF USE THEREOF

The invention provides novel compounds having RIP1 kinase inhibitory activity, pharmaceutical compositions including the compounds and methods of using the compounds.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

A Michael Equilibration Model to Control Site Selectivity in the Condensation toward Aminopyrazoles

A Michael equilibration model is presented to provide for site-selective pyrazole condensations between alkoxyacrylonitriles and hydrazines. Both pyrazole isomers were accessed with high selectivity by employment of kinetically or thermodynamically controlled conditions. Substrate scope and identification of Michael intermediates, as well as competitive pathways, support the presented mechanistic proposal. Sandmeyer derivatization provided site-selective access to fully substituted pyrazoles.

Iodopyrazolyl carboxanilides

This invention relates to novel iodopyrazolylcarboxanilides of the formula (I) t,0010 in which R1, R2, R3, R4, R5, R6 and Z are as defined in the disclosure, to a plurality of processes for preparing these compounds and to their use for controlling unwanted microorganisms. This invention further relates to novel intermediates and their preparation.

IODOPYRAZOLYL CARBOXANILIDES

The invention relates to iodopyrazolyl carboxanilides of formula (I), in which R1, R2, R3, R4, R5, R6 and Z are defined as cited in the description. The invention also relates to several methods for producing said substances and to the use of the latter for controlling undesired micro-organisms, in addition to novel intermediate products and their production.