79990-43-5Relevant academic research and scientific papers
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
Dumas, Jacques,Brittelli, David,Chen, Jinshan,Dixon, Brian,Holia, Hatoum-Mokdad,Koenig, Gerhard,Sibley, Robert,Witowsky, James,Wong, Stephen
, p. 2531 - 2536 (2007/10/03)
Cathepsin D, a lysosomal aspartyl protease, has been implicated in the pathology of Alzheimer's disease as well as breast and ovarian cancer. A weakly active cathepsin D inhibitor was identified by high throughput screening. Subsequent optimization led to
The three conformations of 3,5-dichloro-2-hydroxythiophenol in solution
Schaefer, Ted,Veregin, Richard P.,McKinnon, David M.
, p. 3204 - 3207 (2007/10/02)
The long-range spin-spin coupling constants for the sidechain protons in 3,5-dichloro-2-hydroxythiophenol show that the compound exists as a mixture of three conformers in CCl4 solution at 305 K.The conformer, in which the S-H bond is held roughly perpend
