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80-12-6

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80-12-6 Usage

Description

2,6-Dithia-1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane, 2,2,6,6-tetraoxide, also known as Tetraethylenedisulfotetramine (TETS), is a highly toxic heteroadamantane rodenticide. It is an odorless, tasteless, white crystalline powder that is slightly soluble in water, dimethyl sulfoxide, and acetone. TETS was originally synthesized in 1933 as a resinous condensation product of sulfamide and formaldehyde and used commercially in pillows and upholstery as an impregnating stiffening and antimold agent.

Uses

Used in Pest Control Industry:
TETS is used as a rodenticide for controlling rodents due to its highly effective repellent properties. It was used during reforestation projects to prevent seed predation by rodents. However, due to its high toxicity in mammals, including humans, and its persistence in the environment, many countries banned its production and use in 1984. Despite the ban, TETS continues to be used illicitly as a rodenticide in various regions of the world, particularly in rural areas of China and regions with large Asian populations.
Used in Accidental Poisoning Cases:
TETS has been involved in numerous cases of accidental poisoning, both in humans and animals. For example, in 2003, the first case of TETS intoxication in the United States was reported when a 15-month-old girl was poisoned after accidentally ingesting a rodenticide imported from China that contained TETS.
Used in Intentional Poisoning Cases:
There have been numerous reports of TETS being used to intentionally poison humans. This highly toxic substance has caused thousands of cases of poisoning and hundreds of deaths, particularly in China, where it was found in nearly 50% of commercial rodenticides containing illegal chemicals.

Environmental Fate

Although TETS has a relatively low solubility in water (0.25 mg kg-1), it is quite stable, thus making it relatively persistent in the environment. It is reported that TETS retains biological activity in water for 6 weeks to 5 months after preparation. It is believed that TETS bioaccumulates (despite a predicted octanol:water coefficient of 0.07) and that contact with poisoned animals can result in intoxication, as demonstrated by reports of dogs dying after eating TETS-poisoned rats and by Chinese newspapers warning against consuming meat from dogs that were suspected to have eaten TETS-poisoned rats.

Toxicity evaluation

TETS is a potent convulsant neurotoxicant. TETS has no major effects on peripheral neuromuscular or autonomic transmission and its toxicity appears to be due primarily to actions on the central nervous system. Postmortem studies of TETSpoisoned patients revealed significant pathology in the brain, including degeneration in the basal ganglia, subarachnoid hemorrhages, cerebral and cerebellar bleeding, and brainstem hemorrhages. In cases of extreme intoxication, edema, congestion, and hemorrhages are commonly found in not only the brain but also the heart, lungs, liver, and kidneys. Markers of severe tissue damage (aspartate aminotransferase, alanine aminotransferase, creatine phosphokinase, lactate dehydrogenase, a-hydroxybutyrate dehydrogenase, and creatine phosphokinase isoenzyme MB) are also higher in patients who succumbed to TETS poisoning compared to patients who survived. Additional consequences of TETS intoxication include low potassium levels (hypokalemia), low phosphorus levels (hypophosphatemia), abnormal sodium levels (hypo- or hypernatremia), metabolic acidosis, circulatory hypoxia, and renal tubular damage as demonstrated by elevated levels of Nacetyl- b-D-glucosaminidase and retinol-binding protein. Collectively, these findings are consistent with reports that death following acute TETS intoxication is primarily due to multiple organ dysfunction syndrome. It is generally believed that the convulsant action of TETS is mediated by noncompetitive reversible antagonism of the GABAA receptor chloride channel. TETS blocks g-aminobutyric acid (GABA)-dependent chloride influx in diverse experimental preparations and inhibits the binding of [35S] TBPS to GABAA receptors. GABAA receptors are composed of different subunits (α1–α6, β1–β4, γ1–γ3, δ, ξ, π, and ρ1–ρ3), and require at least one α, β, and γ subunit to be fully functional. TETS is active on native GABAA receptors and recombinantα1β3γ2 receptors, but has no effect on recombinant receptors composed entirely of β3 subunits. Picrotoxin, which similarly induces convulsions via GABA receptor antagonism, is much more selective for the β3 receptor compared to native receptors and the recombinant α1β3γ2 hetero-oligomer.

Check Digit Verification of cas no

The CAS Registry Mumber 80-12-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80-12:
(4*8)+(3*0)+(2*1)+(1*2)=36
36 % 10 = 6
So 80-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H8N4O4S2/c9-13(10)5-1-6-3-8(13)4-7(2-5)14(6,11)12/h1-4H2

80-12-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name tetramine

1.2 Other means of identification

Product number -
Other names DSTA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-12-6 SDS

80-12-6Downstream Products

80-12-6Relevant articles and documents

Acid catalyzed rearrangements of thia and aza analogs of adamantanes a new derivative of sulfamide, formaldehyde and ammonia

Thyagarajan,Kang

, p. 681 - 685 (1974)

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