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Chloramine-B, also known as N-chloro-p-toluenesulfonamide, is a chemical compound with the formula C7H7ClNO2S. It is a white crystalline solid that is soluble in water and has a pungent odor. Chloramine-B is primarily used as a disinfectant and bleaching agent in various applications, including the treatment of drinking water, swimming pools, and industrial processes. It is also used in the textile industry for bleaching and as a biocide in paper mills. The compound is known for its broad-spectrum antimicrobial activity, making it effective against bacteria, viruses, and fungi. However, it is important to handle Chloramine-B with care due to its potential toxicity and environmental impact.

80-16-0

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80-16-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80-16-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 80-16:
(4*8)+(3*0)+(2*1)+(1*6)=40
40 % 10 = 0
So 80-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H6ClNO2S/c7-8-11(9,10)6-4-2-1-3-5-6/h1-5,8H

80-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N-chlorobenzenesulfonamide

1.2 Other means of identification

Product number -
Other names Chloramine-B

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-16-0 SDS

80-16-0Relevant articles and documents

Axinellamines as broad-spectrum antibacterial agents: Scalable synthesis and biology

Rodriguez, Rodrigo A.,Barrios Steed, Danielle,Kawamata, Yu,Su, Shun,Smith, Peter A.,Steed, Tyler C.,Romesberg, Floyd E.,Baran, Phil S.

supporting information, p. 15403 - 15413 (2015/01/09)

Antibiotic-resistant bacteria present an ongoing challenge to both chemists and biologists as they seek novel compounds and modes of action to out-maneuver continually evolving resistance pathways, especially against Gram-negative strains. The dimeric pyrrole-imidazole alkaloids represent a unique marine natural product class with diverse primary biological activity and chemical architecture. This full account traces the strategy used to develop a second-generation route to key spirocycle 9, culminating in a practical synthesis of the axinellamines and enabling their discovery as broad-spectrum antibacterial agents, with promising activity against both Gram-positive and Gram-negative bacteria. While their detailed mode of antibacterial action remains unclear, the axinellamines appear to cause secondary membrane destabilization and impart an aberrant cellular morphology consistent with the inhibition of normal septum formation. This study serves as a rare example of a natural product initially reported to be devoid of biological activity surfacing as an active antibacterial agent with an intriguing mode of action.

Mechanistic studies on the chlorination of phenols with N-chlorobenzene sulphonamide

Meenakshisundaram,Selvaraju

, p. 608 - 615 (2007/10/03)

The effects of substituents on the kinetics and reaction mechanism of chlorination of twenty three meta-, para- and ortho-substituted phenols by N-chlofobenzenesulphonamide (CAB) are reported. The variable order dependence on the substrate concentration for the substituents can be described by the rate equation, -d[CAB]/dt = k′[Ph] [CAB] [H+] + k″ [H 2O] [CAB] [H+]2. The reaction is acid catalysed and its dependence on H0 function suggests the presence of water molecule as a nucleophile in the rate-limiting step. The concave Hammett plot shows a transition in the rate-limiting step with varying nature of the substituents. The linear relation in the Exner plot suggests the operation of a similar mechanism in all the substituted phenols.

Kinetics and mechanism of the reaction of α-phenoxypropanoic acids with sodium salt of N-chlorobenzene-sulphonamide: EDTA catalysis

Meenakshisundaram, Subbiah,Selvaraju

, p. 27 - 33 (2007/10/03)

EDTA smoothly catalyses the oxidation cum chlorination of some 17 α-phenoxypropanoic acids with sodium salt of N-chlorobenzenesulphonamide in acidic solution. A ternary intermediate can be envisaged for describing the enhanced reactivity. Imperfections are observed in the linear Hammett relationship in the case of-NO2 substituents, irrespective of the position. The susceptibility constant, p(≈ + 1) indicates the development of an electron-rich transition state.

Reaction of N,N-dichloroarenesulfonamides with propargyl alcohol

Drozdova,Kozyreva,Mirskova

, p. 243 - 245 (2007/10/03)

The reaction of N,N-dichloroarenesulfonamides with propargyl alcohol gives 3-hydroxy-2,2-dichloro-1,1-di(N-arenesulfonamido)propanes and N-(3-hydroxy-2,2-dichloropropylidene)arenesulfonamides. The latter were obtained due to the transformation of intermediate products, N-chloro-N-(3-hydroxy-2-chloro1-propenyl)arenesulfonamides, by the 1,3-migration of the halogen atom. The addition of arenesulfonamides formed in the reaction to N-(3-hydroxy-2,2-dichloropropylidene)arenesulfonamides results in the formation of 3-hydroxy-2,2-dichloro-1,1-di(N-arenesulfonamido)propanes.

REACTION OF N,N-DICHLOROBENZENESULFONAMIDE WITH 3-CHLORO-1-PROPYNE

Drozdova, T. I.,Kozyreva, O. B.,Levkovskaya, G. G.,Mirskova, A. N.

, p. 409 - 412 (2007/10/02)

The reaction of N,N-dichlorobenzenesulfonamide with 3-chloro-1-propyne gives 2,2,3-trichloro-1,1-di(benzenesulfonamido)propane and N-(2,3-dichloro-1-propenyl)benzenesulfonamide. These are the products from consecutive transformations, i.e., addition of N,N-dichlorobenzenesulfonamide to 3-chloro-1-propyne with the formation of N-chloro-N-(2,3-dichloro-1-propenyl)benzenesulfonamide, its reduction to N-(2,3-dichloro-1-propenyl)benzenesulfonamide or transformation by 1,3-migration of a chlorine atom to N-(2,2,3-trichloropropylidene)benzenesulfonamide, and addition of benzenesulfonamide to the latter with the formation of 2,2,3-trichloro-1,1-di(benzenesulfonamido)propane.

Structure-activity considerations in kinetics and mechanism of chlorine exchange between chloramine-T and secondary amines

Dannan,Hussain,Crooks,Dittert

, p. 657 - 660 (2007/10/02)

To study the mechanism of N-chlorination of secondary amines by chloramine-T, the kinetics of the reactions of some aromatic-substituted analogues of N-chlorobenzenesulfonamide with various secondary amines were determined. The importance of amine basicity and reactivity of the N-Cl bond of the N-chlorobenzenesulfonamide was also assessed. The results indicate that a mechanism involving the un-ionized species of both reactants (i.e., a molecular mechanism), rather than an ionic mechanism, is operating and that the reaction most likely proceeds via a six-membered-ring transition state that incorporates a water molecule.

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