80-51-3

Hazards Identification

Pictogram(s):

Signal:

Danger

GHS Hazard Statements:

H242: Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]
H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes:

P210, P234, P235, P240, P273, P280, P370+P378, P391, P403, P410, P411, P420, and P501

Hazard Classes and Categories:

Self-react. D
Aquatic Acute 1
Aquatic Chronic 1
Self-reactive substances and mixtures - Type D
Serious eye damage/eye irritation - Category 2B
Specific target organ toxicity - Single exposure - Category 2 (nervous system)
Specific target organ toxicity - Repeated exposure - Category 2 (nervous system, haemal system, liver, kidney)
Hazardous to the aquatic environment (Acute) - Category 2
Hazardous to the aquatic environment (Long-term) - Category 1
Specific target organ toxicity - Repeated exposure - Category 1 (nervous system, blood), Category 2 (kidney, liver)
Hazardous to the aquatic environment (Long-term) - Category 2
Acute toxicity (Oral) - Category 5
Flammable - 3rd degree, Reactive - 2nd degree

Hazards Summary:

A skin, eye, and mucous membrane irritant; Moderately toxic by inhalation, ingestion, and skin absorption; [CAMEO] Health effects of exposure to the substance have not been investigated adequately. [ICSC] An irritant; [MSDSonline] Limited toxicology data available; Oral LD50 (rats) = 2.3 g/kg; Dermal LD50 (rabbits) >200 mg/kg; By analogy to the TLV for hydrazine, the recommended TLV for OBSH is sufficiently low to protect against ocular irritation and suspected genotoxicity and carcinogenicity; TLV Basis: Teratogenic effect; [ACGIH]

Usage

Uses

Used in Antimicrobial Applications:
4,4'-Oxybis(benzenesulfonyl hydrazide) is used as an antimicrobial agent for creating masks with an anti-fog function. This application helps to prevent the spread of infections and provides a clear view for the wearer.
Used in Personal Protective Equipment Industry:
In the personal protective equipment industry, 4,4'-Oxybis(benzenesulfonyl hydrazide) is used as an antimicrobial component in the production of masks. Its incorporation into mask materials helps to inhibit the growth of bacteria and viruses, enhancing the safety and effectiveness of the masks.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4,4'-Oxybis(benzenesulfonyl hydrazide) is an azide. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.

Flammability and Explosibility

Notclassified

Safety Profile

Mutation data reported. A flammable solid. When heated to decomposition it emits very toxic fumes of NOx and SOx

Synthetic route

4,4'-bis(sulfonic acid)diphenyl ether (3232-24-4) → diphenylether-4,4'-disulfonyl hydrazide (80-51-3)

Conditions	Yield
With carbazic acid In neat (no solvent) at 100℃; for 5h; Reagent/catalyst; Green chemistry;	97%

4,4'-oxybis(benzenesulfonyl chloride) (121-63-1) → diphenylether-4,4'-disulfonyl hydrazide (80-51-3)

Conditions	Yield
With carbazic acid In neat (no solvent) at 100℃; for 5h; Reagent/catalyst; Temperature; Solvent; Green chemistry;	91%
With hydrazine
With hydrazine hydrate

diphenylether-4,4'-disulfonyl hydrazide (80-51-3) → 4,4′-disulfonylazidophenyl ether

Conditions	Yield
With hydrogenchloride; sodium nitrite In methanol; water at 0℃; Temperature; Solvent;	96%
With acetic acid; sodium nitrite

diphenylether-4,4'-disulfonyl hydrazide (80-51-3) + phenylacetylene (536-74-3) → (E)-1,1'-((2,2'-iodo-2-phenylvinyl)-4,4'-oxybis(benzenesulfonyl)vinyl)benzene

Conditions	Yield
With sodium iodide In chloroform; water at 20℃; for 5h; Electrolysis; stereoselective reaction;	75%

1-ethoxy-4,5-dihydro-3H-benzo[4,5]thieno[2,3-c]azepine (50491-70-8) + diphenylether-4,4'-disulfonyl hydrazide (80-51-3) → 4,4'-oxy-bis-benzenesulfonic acid bis-[(2,3,4,5-tetrahydro-benzo[4,5]thieno[2,3-c]azepin-1-ylidene)-hydrazide] (50491-76-4)

Conditions	Yield
In ethanol for 22h; Heating;

Upstream product

• 121-63-1 4,4'-oxybis(benzenesulfonyl chloride) 
• 3232-24-4 4,4'-bis(sulfonic acid)diphenyl ether 

Relevant academic research and scientific papers

PREPARING METHOD OF HYDRIZIDE COMPOUNDS

The present invention relates to a method for preparing hydrazide and, more specifically, to a method for preparing a hydrazide derivative compound by reacting a hydrazine-carbon dioxide coupled compound with an organic acid or sulfonic acid compound.COPYRIGHT KIPO 2015