80025-72-5

Usage

Uses

Used in Organic Synthesis:
2,4,6-TRIFLUOROPHENYLHYDRAZINE is used as a synthetic intermediate for the preparation of various organic compounds. Its reactivity allows it to participate in a wide range of chemical reactions, making it a valuable building block in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
2,4,6-TRIFLUOROPHENYLHYDRAZINE is used as a key component in the development of pharmaceutical compounds. Its unique structure and reactivity enable the creation of new drugs with potential therapeutic applications.
Used in the Synthesis of Propionic Acid Derivatives:
2,4,6-TRIFLUOROPHENYLHYDRAZINE is used as a reactant in the preparation of propionic acid (2,4,6-trichlorophenyl)hydrazide. 2,4,6-TRIFLUOROPHENYLHYDRAZINE is synthesized by reacting 2,4,6-TRIFLUOROPHENYLHYDRAZINE with propionyl chloride in pyridine, which can be further utilized in the development of pharmaceutical agents.
Used in the Formation of Hydrazones:
2,4,6-TRIFLUOROPHENYLHYDRAZINE is used in the formation of hydrazones, such as Visnaginone Ia, by reacting with phenyl hydrazine and 2,4,6-trichlorophenyl hydrazine. These hydrazones have potential applications in various fields, including pharmaceuticals and materials science.

InChI:InChI=1/C6H5F3N2/c7-3-1-4(8)6(11-10)5(9)2-3/h1-2,11H,10H2

Upstream product

• 363-81-5 2,4,6-trifluoroaniline 

Downstream Products

• 1356054-91-5 1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356054-89-1 4-iodo-1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridine 
• 1356054-90-4 (E)-2-fluoro-4-iodo-3-((2-(2,4,6-trifluorophenyl)hydrazono)methyl)pyridine 

Relevant academic research and scientific papers

Synthesis, insecticidal activities, and structure-activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety

Fluorinated organic compounds represent a growing and important family of commercial chemicals. Introduction of fluorine into active ingredients has become an effective way to develop modern crop protection products. Given the particular properties of fluorine and high efficiency and selectivity of diamide insecticides, we designed and synthesized 27 anthranilic diamides analogues containing fluoro-sustituted phenylpyrazole. A preliminary bioassay indicated that most target compounds exhibited good biological activity against Mythimna separata and Plutella xylostella. Compound IIIf containing a 2,4,6-trifluoro-substituted benzene ring showed 43% insecticidal activity against M. separata at 0.1 mg L-1, while the control chlorantraniliprole was 36%. The activity of IIIe against P. xylostella at 10-5 mg L-1 was 94%, compared with that of the control being 70%. Thus, introduction of fluorine into diamide insecticides was useful for increasing activity. Insect electrophysiology studies showed that the calcium concentration in the nerve cells of third M. separata larvae was elevated by IIIf, which further confirmed that ryanodine receptor (RyR) was its potential target.

N-Phenylpyrazole derivatives

N-Phenylpyrazole derivatives of the formula: STR1 (wherein each of R5 and R6 represents a C1 -C4 alkyl or alkoxy radical, a trifluoromethyl, trifluoromethoxy, nitro, cyano or primary amino radical, or a fluorine, chlorine or bromine atom, each of R7, R8 and R9 represents a hydrogen atom, a C1 -C4 alkyl or alkoxy radical, a trifluoromethyl, trifluoromethoxy, nitro, cyano or primary amino radical or a fluorine, chlorine or bromine atom, or R5, R7, R8 and R9 each represents a hydrogen atom and R6 represents a trifluoromethoxy or trifluoromethyl radical, and R10 represents a cyano radical or substituted carbamoyl radical --CONHR11, wherein R11 represents a methyl or ethyl radical) have been found to possess useful herbicidal properties. All such N-phenylpyrazole derivatives with the exception of 5-amino-4-cyano-1-(2,4-dichlorophenyl)pyrazole and 5-amino-4-cyano-1-(4-chloro-2-methylphenyl)pyrazole are new compounds. Herbicidal compositions containing such N-phenylpyrazole derivatives are described and also processes for the preparation of the new compounds.