80025-72-5

Basic information

• Product Name: 2,4,6-TRIFLUOROPHENYLHYDRAZINE
• Synonyms: 2,4,6-TRIFLUOROPHENYLHYDRAZINE;2,4,6-Trifluorophenylhydrazine97+%;2,4,6-Trifluorophenylhydrazine80025-72-5;1-Hydrazino-2,4,6-trifluorobenzene;2-Hydrazino-1,3,5-trifluorobenzene
• CAS NO: 80025-72-5
• Molecular Formula: C₆H₅F₃N₂
• Molecular Weight: 162.11
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes
• Mol File: 80025-72-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 97-99°C
• Boiling Point: 142.4°C at 760 mmHg
• Flash Point: 39.9°C
• Appearance: /
• Density: 1.491g/cm³
• Vapor Pressure: 5.59mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: 2-8°C
• PKA: 4.31±0.33(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 2,4,6-TRIFLUOROPHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIFLUOROPHENYLHYDRAZINE(80025-72-5)
• EPA Substance Registry System: 2,4,6-TRIFLUOROPHENYLHYDRAZINE(80025-72-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• Hazardous Substances Data: 80025-72-5(Hazardous Substances Data)

Usage

Uses

Propionic acid (2,4,6-trichlorophenyl)hydrazide was prepared by reaction of (2,4,6-trichlorophenyl)- hydrazine with propionyl chloride in pyridine. Visnaginone Ia reacted with phenyl hydrazine and 2,4,6- trichlorophenyl hydrazine to yield the corresponding hydrazones.

InChI:InChI=1/C6H5F3N2/c7-3-1-4(8)6(11-10)5(9)2-3/h1-2,11H,10H2

Upstream product

• 363-81-5 2,4,6-trifluoroaniline 

Downstream Products

• 1356054-91-5 1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-ylboronic acid 
• 1356054-89-1 4-iodo-1-(2,4,6-trifluorophenyl)-1H-pyrazolo[3,4-b]pyridine 
• 1356054-90-4 (E)-2-fluoro-4-iodo-3-((2-(2,4,6-trifluorophenyl)hydrazono)methyl)pyridine 

Relevant articles and documents

Synthesis, insecticidal activities, and structure-activity relationship of phenylpyrazole derivatives containing a fluoro-substituted benzene moiety

Fluorinated organic compounds represent a growing and important family of commercial chemicals. Introduction of fluorine into active ingredients has become an effective way to develop modern crop protection products. Given the particular properties of fluorine and high efficiency and selectivity of diamide insecticides, we designed and synthesized 27 anthranilic diamides analogues containing fluoro-sustituted phenylpyrazole. A preliminary bioassay indicated that most target compounds exhibited good biological activity against Mythimna separata and Plutella xylostella. Compound IIIf containing a 2,4,6-trifluoro-substituted benzene ring showed 43% insecticidal activity against M. separata at 0.1 mg L-1, while the control chlorantraniliprole was 36%. The activity of IIIe against P. xylostella at 10-5 mg L-1 was 94%, compared with that of the control being 70%. Thus, introduction of fluorine into diamide insecticides was useful for increasing activity. Insect electrophysiology studies showed that the calcium concentration in the nerve cells of third M. separata larvae was elevated by IIIf, which further confirmed that ryanodine receptor (RyR) was its potential target.