800401-65-4

Basic information

• Product Name: 5-AZAINDOLE-2-CARBOXYLIC ACID
• Synonyms: 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID;5-AZAINDOLE-2-CARBOXYLIC ACID;5-Azaindole-5-carboxylic acid;1H-pyrrolo[3,2-c]pyridine-2-carbo×ylic acid;[3,2-c]pyridine-2-carboxylic acid
• CAS NO: 800401-65-4
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.15
• EINECS: 1.506 g/cm³
• Product Categories: Azaindoles
• Mol File: 800401-65-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 446.8 °C at 760 mmHg
• Flash Point: 224 °C
• Appearance: /
• Density: 1.507g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: 2-8°C
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 3.44±0.30(Predicted)
• CAS DataBase Reference: 5-AZAINDOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AZAINDOLE-2-CARBOXYLIC ACID(800401-65-4)
• EPA Substance Registry System: 5-AZAINDOLE-2-CARBOXYLIC ACID(800401-65-4)

Safety Data

• Hazardous Substances Data: 800401-65-4(Hazardous Substances Data)

Usage

General Description

5-Azaindole-2-carboxylic Acid, also identified with CAS number 371242-69-2, is a chemical compound known for its potential application in medicinal chemistry. It is an important synthetic intermediate that can be utilized in the creation of various pharmaceutical agents. This aromatic compound belongs to the class of organic compounds known as Pyrrolopyridines. Although it has not been largely studied, this chemical is expected to possess unique properties attributed to its azaindole structure, which may have relevance in drug design and synthesis. Its precise effects, applications, and safety profile continue to be areas of ongoing research.

InChI:InChI=1/C8H6N2O2/c11-8(12)7-3-5-4-9-2-1-6(5)10-7/h1-4,10H,(H,11,12)

Upstream product

• 1990-90-5 4-amino-3-methylpyridine 
• 88511-27-7 3-iodopyridin-4-amine 
• 127-17-3 2-oxo-propionic acid 
• 504-24-5 4-aminopyridine 
• 271-34-1 5-azaindole 
• 800401-64-3 ethyl 1H-pyrrolo[3,2-c]pyridine-2-carboxylate 

Relevant articles and documents

A medicine intermediate 5 - aza indole synthesis method (by machine translation)

The present invention discloses a pharmaceutical intermediate 5 - aza indole synthesis method, comprises the following steps: the 3 - methyl - 4 - aminopyridine with acetone after mixing, heating to 40 - 60 °C, adding catalyst after adding the oxalate, under stirring conditions, refluxing reaction 1 - 2 h, filtering, the filtrate by reduced pressure distillation, recrystallization, prepared 4 - aminopyridine - 3 - pyruvate ester; in its entry into the DMA, adding salicylic acid then adding the FeO, heated to 60 - 70 °C, stirring reflux reaction for 2 - 3 h, filter, the filtrate is distilled under reduced pressure, to obtain 5 - aza indole - 2 - carboxylic acid; and after mixing with the carbon tetrachloride, heating to 70 - 90 °C, adding ZnO mixing, stirring reflux reaction for 2 - 3 h after, filtering, the filtrate is distilled under reduced pressure, to obtain 5 - azaindole. The application of the synthesis method is simple in operation, mild condition, less by-products, the product has high purity, product yield is relatively high. (by machine translation)

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.