80041-80-1

Basic information

• Product Name: 5-(2-bromo-4,5-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
• Synonyms: 5-(2-bromo-4,5-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
• CAS NO: 80041-80-1
• Molecular Weight: 404.26
• Mol File: 80041-80-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5-(2-bromo-4,5-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-bromo-4,5-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline(80041-80-1)
• EPA Substance Registry System: 5-(2-bromo-4,5-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline(80041-80-1)

Safety Data

• Hazardous Substances Data: 80041-80-1(Hazardous Substances Data)

Upstream product

• 1485-00-3 5-((E)-2-nitroethenyl)-1,3-benzodioxole 
• 120-57-0 piperonal 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 6831-57-8 2-bromo-4,5-dimethoxyphenylacetic acid chloride 
• 4697-62-5 6-bromohomoveratric acid 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 25829-00-9 N-(2-(benzo[d] [1,3]dioxol-5-yl)ethyl)-2-(2-bromo-4,5-dimethoxyphenyl)acetamide 

Downstream Products

• 517-66-8 (S)-dicentrine 
• 16408-78-9 dicentrinone 
• 80041-83-4 1-(2-Bromo-4,5-dimethoxy-phenyl)-4,5-dihydro-7,9-dioxa-3a-aza-dicyclopenta[a,g]naphthalene-2,3-dione 
• 25888-41-9 1-(2-bromo-4,5-dimethoxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Enantioselective synthesis and anti-parasitic properties of aporphine natural products

Chagas disease and visceral leishmaniasis are neglected protozoan diseases with significant impact in developing countries. Due to the limited number and toxicity of current therapies, new drug leads are urgently needed. In this work, four aporphine natural products were synthesized using an enantioselective, modular and convergent strategy, comprising eight steps in the longest linear sequence; key steps included Bischler-Napieralski cyclization/Noyori asymmetric reduction to construct the tetrahydroisoquinolines, and palladium-catalyzed arylation to close the C ring. Norglaucine, nordicentrine and dicentrine showed promising bioactivity against T. cruzi and L. infantum, suggesting potential for further development of these scaffolds as antiparasitic agents.

Synthesizing method of oxidized dicentrine

The invention discloses a synthesizing method of oxidized dicentrine. The synthesizing method comprises the following steps of using 3,4-dimethoxyphenylacetic acid as the start raw material, reactingwith bromine to obtain a product, and then reacting with

Bromated oxidated dicentrine and synthesis method and application thereof

The invention discloses bromated oxidated dicentrine and a synthesis method and application thereof. The synthesis method of the bromated oxidated dicentrine comprises the steps of subjecting 3,4-dimethoxyphenylacetic acid, which serves as a starting raw