80045-93-8

Upstream product

• 50-00-0 formaldehyd 
• 120-18-3 naphthalene-2-sulfonate 
• 129453-04-9 8,8'-methylenbis-5-bromo-2-naphthalensulfonic acid 
• 119-79-9 5-aminonaphthalene-2-sulfonic acid 
• 129453-03-8 sodium 5-bromo-2-naphthalensulfonate 

Relevant academic research and scientific papers

Compound for inhibiting HIV infectivity

This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.

Sulfonic acid and aldehyde condensation polymers for preventing pregnancy

This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can prevent pregnancy in an individual.

Compound for inhibiting HIV infectivity

This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalene-sulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.

Compound for inhibiting HIV infectivity

This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalene-sulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.

Synthesis and structural characterization of regiocontrolled oligomers from 2-naphthalensulfonic acid and formaldehyde

Regiocontrolled synthesis of symmetrical dinuclear products 4 and 8 derived from condensation of 2-naphthalensulfonic acid and formaldehyde was afforded. Acid catalyzed reaction of 4 with formaldehyde gave a mixture of regiocontrolled oligomers with even number of naphthalenic nucleus from which tetranuclear 9 and hexanuclear 10 products were separated. NMR Studies of all these products were carried out, obtaining both the structural characterization and useful informations for the identification of more complex mixtures.

METHYLENE BRIDGE POSITION IN 2-NAPHTHALENSULFONIC ACID-FORMALDEHYDE CONDENSATION PRODUCTS: A NMR INVESTIGATION

Low molecular weight oligomers from acid catalyzed condensation of 2-naphthalensulfonic acid and formaldehyde were obtained.Spectroscopic (NMR) studies of dinuclear mixture verified the presence of 5,5'- 8,8'- and 5,8'-methylenebis-2-naphthalensulfonic acid, with a predominance of products derived from 5-attack.Trinuclear product confirmed the presence of a linear structure of these condensate.Similar results were also obtained from dinuclear product separated from commercial product (Daxad 15-Grace).