80054-97-3

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 140-10-3 (E)-3-phenylacrylic acid 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 1407150-78-0 C₂₇H₂₈N₂O₂ 

Downstream Products

• 14399-14-5 threo-(1R,2R)-1-(4-nitrophenyl)-2-(dichloroacetamido)-1,3-propanediol 3-cinnamate 
• 1178910-36-5 C₁₉H₂₁F₃O₂Si 
• 23522-66-9 2,2,2-trifluoroethyl 3-phenylpropanoate 
• 1039768-40-5 (S)-3-(dimethylphenylsilyl)-3-phenylpropanoic acid 2,2,2-trifluoroethyl ester 
• 52392-64-0 (E)-3-(phenyl)acrylic acid butyl ester 

Relevant academic research and scientific papers

Aromatic carboxylic acid trifluoro ethyl ester compound and its preparation method (by machine translation)

Aromatic carboxylic acid trifluoro ethyl ester compound and its preparation method. The present invention provides a kind of aromatic carboxylic acid trifluoroacetate ester compound and its preparation method, the method is that the aromatic carboxylic acid and nitrous acid tert-butyl and 2, 2, 2 - trifluoro ethylamine one-pot synthesis after reaction, to obtain the carboxylic acid trifluoroacetate ester compound. The method is simple in operation, mild reaction conditions, low cost, few by-products, high yield, can be aromatic carboxylic acid trifluoroacetate ester compound, not limited by substrate, in order to establish aromatic carboxylic acid trifluoroacetate ester compound library, for drug screening and new drug synthesis of the raw material sources. (by machine translation)

μ-Oxo-Dinuclear-Iron(III)-Catalyzed O-Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of Tertiary Alcohols

A highly chemoselective and reactive μ-oxo-dinuclear iron(III) salen catalyst for transesterification was developed. The developed iron complex catalyzed acylation of aliphatic amino alcohols with nearly perfect O-selectivity, even when using activated esters, for which chemoselectivity is more difficult to control. In addition, O-selective transesterification of aromatic amino alcohols was achieved for the first time. The high activity of the iron complex enabled the use of sterically congested tertiary alcohols, including unprecedented tert-butanol.

A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification

We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields.

Correlation of the rates of solvolyses of cinnamyl chloride

Solvolytic rate constants (k) at 25 °C are reported for solvolyses of cinnamyl chloride (1) in binary mixtures of water with acetone, ethanol, methanol, methanol-d and 2,2,2-trifluoroethanol (TFE), and also in TFE-ethanol mixtures; product selectivities (S) are reported for aqueous ethanol and methanol: S = [ether product]/[alcohol product] × [water]/[alcohol solvent]. A good correlation observed between log k and the parameter YCl (solvent ionizing power) is improved only slightly by additional parameters (N for solvent nucleophilicity and/or I, an aromatic ring parameter). Rate ratios in solvents of the same YCl value but different nucleophilicities provide measures of the minimum extent of nucleophilic solvent assistance, and the value of 1.48 for [k40EW/k97TFE]Y (EW = ethanol-water) is consistent with an essentially SN1 reaction mechanism. A linear relationship between 1/S and molar ratio of solvent was derived theoretically and validated experimentally for solvolyses of the above substrate from water up to 75% alcohol-water. The dependence of S on solvent composition and the absence of rate depression in the presence of added chloride anions are explained by product formation via a contact ion pair. Copyright