80082-51-5Relevant articles and documents
Preparation method of amino-2-methyl-4-oxo-1-azetidinesulfonic acid intermediate
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Paragraph 0023-0035, (2020/08/25)
The invention discloses a preparation method of an amino-2-methyl-4-oxo-1-azetidinesulfonic acid intermediate, comprising the following steps: S1, adding N-carbobenzoxy-L-threonine amide into a reaction vessel, adding an organic solvent, stirring, mixing, adding 2-methylpyridine and methylsulfonyl chloride, heating, and carrying out a thermal reaction to obtain a reaction solution I; S2, cooling the reaction solution I to below 0 DEG C, then adding chlorosulfonic acid into the cooled reaction solution I, heating, carrying out a thermal reaction to obtain a reaction solution II, and cooling; and S3, adding deionized water into the cooled reaction solution II for a quenching reaction, then adding alkali liquor into the reaction system to adjust the pH, heating, and carrying out a thermal reaction. The method adopts a one-pot method for synthesis, is simple in process operation and short in period, avoids the generation of three wastes, and realizes the production of a green process; thepurity of the obtained amino-2-methyl-4-oxo-1-azetidinesulfonic acid intermediate is as high as 98.5%, the molar yield is as high as 80.9%, the product quality is good, and the method is suitable forindustrial production.
