80087-69-0

Usage

Structure

A heterocyclic compound containing a benzene ring fused to a thiazole ring with two chlorine atoms attached to the 5th and 6th carbon atoms.

Type

A derivative of benzothiazolethione.

Industrial applications

Used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Research interest

Potential biological activities and of interest to researchers in the fields of medicinal chemistry and drug discovery.

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 636-30-6 2,4,5-trichloroaniline 
• 75-15-0 carbon disulfide 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 

Downstream Products

• 21564-21-6 2-(5,6-Dichlorbenzthiazolyl)thiomethylthiocyanat 

Relevant academic research and scientific papers

Synthesis of chloro-substituted analogs of Thiazole orange - Fluorophores for flow cytometric analyses

Synthesis, absorption and fluorescence properties of a series of asymmetrical monomethine cyanine dyes, chloro-containing analogs of Thiazole orange, are reported. Their staining ability was studied by flow cytometry. The saturating concentrations of each dye that gives a stable staining intensity have been determined. The ability of dyes B9, B11, B13 to stain live macrophages and apoptotic splenocytes was investigated. Positive signal in nucleus of adherent macrophages detected by fluorescent microscopy showed good specificity of B9, B11 and B13 dyes for DNA. In apoptotic assay cells positive for Annexin V were stained more brightly with the dyes B9, B11 and B13 than with propidium iodide. Despite that B13 showed high DNA selectivity it induces apoptosis of splenocytes and it is not suitable for detection of dead cells. The other synthesized chloro-containing analogs of Thiazole orange B9 and B11 can be successfully used for flow cytometric analyses of DNA content in live cells and for analyses of cell apoptosis.

COMPOUNDS FOR MODULATING TRPV3 FUNCTION

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Process for the preparation of 2-mercaptobenzothiazoles

The preparation of (optionally substituted) 2-mercaptobenzothiazole by reaction of corresponding 2-halogenoanilines with an alkali metal xanthate or alkaline earth metal xanthate or with CS2 in the presence of bases.