80092-76-8

Upstream product

• 91700-87-7 7-chloro-3-(2,4-dichlorophenyl)-1,2,3,4,9,10-hexahydroacridine-1,9-dione 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 55579-70-9 5-(2,4-dichloro-phenyl)-cyclohexane-1,3-dione 
• 66896-92-2 4-(2',4'-dichlorophenyl)-3-buten-2-one 
• 4743-17-3 5-Chloroisatoic anhydride 

Relevant academic research and scientific papers

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.

7-Chloro-3-substituted aryl-3,4-dihydro-1,9(2H,10H) and 10 hydroxy acridinedioneimines having antimalarial activity

7-Chloro-3-substituted aryl-3,4-dihydro-1,9-(2H,1OH) and 10-hydroxy-acridinedioneimines and their pharmaceutically acceptable salts and a process for preparing them are disclosed and claimed. The compounds are useful in the treatment of protozoan diseases