80096-22-6Relevant academic research and scientific papers
Synthesis and screening of 2-(2-(4-substituted piperazine-1-yl)-5- phenylthiazol-4-yl)-3-aryl quinazolinone derivatives as anticancer agents
Sharma, Ritesh N.,Ravani, Rasik
, p. 2788 - 2794 (2013/07/26)
Synthesis of novel quinazolinone derivatives was performed from the reaction of N-benzoyl substituted piperazine-1-carbothioamide with 2-chloromethyl quinazolinone derivatives and screened for their in vitro cytotoxic activity by MTT assay. The cell lines
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors
Huang, Wenwei,Huang, Ruili,Attene-Ramos, Matias S.,Sakamuru, Srilatha,Englund, Erika E.,Inglese, James,Austin, Christopher P.,Xia, Menghang
supporting information; experimental part, p. 5239 - 5243 (2011/10/02)
Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the synthes
Quinazolinones, 2. Syntheses and Some Reactions of 2-Azido-methyl-3-aryl-4-quinazolinones
Domanig, Rainer
, p. 1195 - 1202 (2007/10/02)
Starting with the chloromethyl compounds 7 the new 2-azidomethyl-3-aryl-4-quinazolinones 8a-h were prepared, some of which have been reduced so far to the corresponding amines 9a, b, e, g by H2S in good yield.As a first example for the capability of the a
