80096-48-6

Upstream product

• 1638623-17-2 C₁₂H₁₇ClO₂Si 
• 121-97-1 4-Methoxypropiophenone 
• 21086-33-9 2-bromo-1-(4-methoxyphenyl)-1-propanone 
• 313692-52-3 (±)-2-azido-1-(4-methoxyphenyl)propan-1-one 

Downstream Products

• 308143-11-5 2-amino-3-cyano-4-(4-methoxyphenyl)-5-methylpyrrole 
• 50802-67-0 erythro-2-amino-1-(4-methoxyphenyl)propan-1-ol 

Relevant academic research and scientific papers

Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents

The functionalization of carbonyl compounds in the α-position has gathered much attention as a synthetic route because of the wide biological importance of such products. Through polarity reversal, or "umpolung", we show here that typical nucleophiles, such as oxygen, nitrogen, and even carbon nucleophiles, can be used for addition reactions after tethering them to enol ethers. Our findings allow novel retrosynthetic planning and rapid assembly of structures previously accessible only by multistep sequences. A Nu approach: An efficient α-functionalization of ketones with a range of simple and useful nucleophiles is possible by using hypervalent iodine reagents (see scheme; Nu′ can be the Nu itself or a protected form of this nucleophile group).

Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists

Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed. 2-(2-Methylaminoethyl)pyridine was discovered to be a key feature for generating active compounds. The best compound from the series had 25 nM (Ki) binding affinity to human GnRH receptor.