80099-61-2Relevant academic research and scientific papers
Photocyclization Reactions. Part 5 [1]. Synthesis of Dihydrobenzofuranols Using Photocyclization of 2-Alkoxybenzophenones and Ethyl 2-Benzoylphenoxyacetates
Sharshira, Essam Mohamed,Shimada, Satoru,Okamura, Mutsuo,Hasegawa, Eietsu,Horaguchi, Takaaki
, p. 1797 - 1805 (1996)
Photocyclization reactions were carried out on 2-alkoxybenzophenones 1a-h and ethyl 2-benzoylphenoxyacetates 2a-e in acetonitrile. Irradiation of 1a-h gave dihydrobenzofuranols 4a-h in 68-84% yields. Similarly, irradiation of 2a-e afforded dihydrobenzofuranols 8a-e in 72-75% yields. Ethyl acrylates 9b-c were also produced in 6-8% yields from photoreactions of 2b-c. Substituent effects on cyclization of 1,5-biradical intermediates and reaction pathways are discussed. Benzophenones are useful compounds to prepare dihydrobenzofuranols by photocyclization.
Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives
Walsh,Sleevi,Sancilio
, p. 1317 - 1321 (2007/10/02)
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxygenase enzyme by a mechanism first proposed by Appleton and Brown. Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model.
