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Usage

Uses

Used in Pharmaceutical Industry:
6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE is used as a key intermediate for the synthesis of various pyridine derivatives, which are essential components in the development of pharmaceuticals. Its reactivity with amines and alcohols makes it a valuable reagent in the production of diverse chemical products.
Used in Agrochemical Industry:
6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE is used as a building block in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE is used as a reagent in organic synthesis due to its reactivity with amines and alcohols, enabling the creation of a wide range of chemical products across various industries.

Upstream product

• 21190-87-4 6-bromo-pyridine-2-carboxylic acid 

Downstream Products

• 263270-42-4 N-{3-[3-(4-methylpiperazin-1-ylmethyl)benzamido]-4-methylphenyl}-6-chloropyridine-2-carboxamide 
• 137640-93-8 N-(2,4-difluorophenyl)-2-chloro-6-pyridinecarboxamide 
• 137640-94-9 6-chloro-N-(4-fluorophenyl)pyridin-2-amide 
• 98142-19-9 6-chloropyridine-2-carbohydrazide 
• 847622-55-3 N-(2,6-dimethyl-4-heptafluoroisopropyl)phenyl 6-chloropyridine-2-carboxylic acid amide 
• 1373270-97-3 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide 
• 1373270-61-1 2-phenyl-1-(6-{4-[1-(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl}pyridin-2-yl)ethan-1-one 
• 1373272-66-2 6-[(1-benzylpiperidin-4-yl)oxy]-N-(pyridin-4-yl)pyridine-2-carboxamide 
• 1373272-65-1 6-[(1-benzylpiperidin-4-yl)oxy]pyridine-2-carboxylic acid 
• 1373272-10-6 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]pyridine-2-carboxylic acid 
• 6636-55-1 methyl 6-chloropicolinate 
• 1280786-59-5 tert-butyl 6-chloropyridine-2-carboxylate 

Relevant academic research and scientific papers

QUINOLINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS

Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure (I) and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, X, Y1, Y2, Y3 and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.

Process for the preparation of azine-carboxylic acid chlorides

The invention relates to an effective and efficient process for the preparation of azinyl acid chloride compounds of formula I, wherein, Az represents an optionally substituted azinyl group, which comprises heating a trichloromethylazine of formula II Az-CCl3wherein Az has the meaning given,with an acid, that forms an acid chloride, which can be distilled off during the reaction under reduced pressure, in the presence of an acidic catalyst;, ???and to the use of the compounds of formula I obtained according to this process for the preparation of (hetero)aryloxyazinylcarboxamides of formula VI in which Az has the meaning given in any of the preceding claims, and, Ar represents an optionally substituted aryl or heteroaryl group,R3represents a hydrogen atom or an alkyl group, and, R4represents an optionally substituted alkyl, aryl, heteroaryl or cycloalkyl group.