6-chloropyridine-2-carbonyl Chloride

Base Information

• Chemical Name: 6-chloropyridine-2-carbonyl Chloride
• CAS No.: 80099-98-5
• Molecular Formula: C6H3 Cl2 N O
• Molecular Weight: 176.002
• Hs Code.: 2933399090
• European Community (EC) Number: 863-542-4
• DSSTox Substance ID: DTXSID00449177
• Wikidata: Q72458457
• Mol file: 80099-98-5.mol

Synonyms:80099-98-5;6-chloropyridine-2-carbonyl Chloride;6-chloropicolinoyl chloride;6-CHLORO-PYRIDINE-2-CARBONYL CHLORIDE;2-Pyridinecarbonyl chloride, 6-chloro-;2-Pyridinecarbonylchloride, 6-chloro-;6-chloro-2-Pyridinecarbonyl chloride;6-chloropicolinoylchloride;SCHEMBL1766284;DTXSID00449177;INDXGKMKACLIJS-UHFFFAOYSA-N;MFCD00274531;AKOS006271936;AS-9661;2-chloropyridine-6-carboxylic acid chloride;6-chloro-2-pyridinecarboxylic acid chloride;FT-0765840;C76563;EN300-130273

Chemical Property of 6-chloropyridine-2-carbonyl Chloride

Chemical Property:

• Boiling Point: 239.0±20.0 °C(Predicted)
• PKA: -2.22±0.10(Predicted)
• PSA: 29.96000
• Density: 1.454±0.06 g/cm3(Predicted)
• LogP: 2.11400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 174.9591691
• Heavy Atom Count: 10
• Complexity: 140

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

6-Chloropyridine-2-carbonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)Cl)C(=O)Cl

Technology Process of 6-chloropyridine-2-carbonyl Chloride

There total 2 articles about 6-chloropyridine-2-carbonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-chloropicolinoyl chloride (80099-98-5) + methanesulfonyl chloride (124-63-0)

Guidance literature:

Reference yield:

6-bromo-pyridine-2-carboxylic acid (21190-87-4) → 6-chloropicolinoyl chloride (80099-98-5) + 6-bromopyridine-2-carbonyl chloride (139487-69-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; for 3h; Reflux;

Reference yield: 82.0%

6-chloropicolinic acid (4684-94-0) + 6-chloropicolinoyl chloride (80099-98-5) + 4-fluoroaniline (371-40-4) → 6-chloro-N-(4-fluorophenyl)pyridin-2-amide (137640-94-9)

Guidance literature:

In thionyl chloride; diethyl ether; water;

upstream raw materials:

6-bromo-pyridine-2-carboxylic acid

Downstream raw materials:

N-{3-[3-(4-methylpiperazin-1-ylmethyl)benzamido]-4-methylphenyl}-6-chloropyridine-2-carboxamide

N-(2,4-difluorophenyl)-2-chloro-6-pyridinecarboxamide

6-chloro-N-(4-fluorophenyl)pyridin-2-amide

6-chloropyridine-2-carbohydrazide

Refernces

• 1、 -. "Process for the preparation of azine-carboxylic acid chlorides". . . Retrieved 2008/06/13.