80100-34-1Relevant academic research and scientific papers
First one-pot chemo-, regio- and enantioselective functionalisation of pyridine compounds mediated by BuLi-(S)-(-)-N-methyl-2-pyrrolidine methoxide
Fort, Yves,Gros, Philippe,Rodriguez, Alain L.
, p. 2631 - 2635 (2001)
BuLi-(S)-(-)-N-methyl-2-pyrrolidine methoxide (noted BuLi-LiPM*) is the first superbase promoting an unprecedented regioselective C-6 lithiation of pyridine compounds while controlling the asymmetric addition on aldehydes.
TMSCH2Li-LiDMAE: a new nonnucleophilic reagent for C-2 lithiation of halopyridines
Doudouh, Abdelatif,Gros, Philippe C.,Fort, Yves,Woltermann, Christopher
, p. 6166 - 6171 (2007/10/03)
A new superbasic reagent has been discovered by combining TMSCH2Li and LiDMAE in hexane. This reagent was found highly efficient for the C-2 lithiation of sensitive chloro- and fluoropyridines. The metallation occurred chemo- and regioselectively at 0 °C avoiding the nucleophilic addition or substrate degradation commonly obtained with other alkyllithiums even at lower temperatures.
Preparation and reactions of pyridinyl tellurides
Shilai,Uchiyama,Kondo,Sakamoto
, p. 481 - 484 (2007/10/03)
Tellurium-metal exchange reaction of n-butyl 2-pyridinyl telluride derivatives with n-butyllithium or dilithium dimethylcyanocuprate proceeded smoothly to give the corresponding 2-pyridinylmetal derivatives, which are important intermediates for functionalization of pyridines.
2-halo-pyridines
-
, (2008/06/13)
2-Halo-pyridines of the general formula I STR1 wherein X is Cl or Br; A is =0 or STR2 Ar is phenyl or substituted phenyl of the general formula STR3 in which n is 0, 1, 2 or 3; R is alkyl C1-4, alkoxy C1-4, phenoxy, alkylthio C1-4, halogen especially F and Cl, OH or C6 H5 ; and their salts, addition compounds and precursors (prodrugs). Furthermore the invention is directed to the production of these compounds and pharmaceuticals containing them.
