80103-18-0Relevant academic research and scientific papers
Adamantane-retropeptides, new building blocks for molecular channels
Basari?, Nikola,Mol?anov, Kre?imir,Matkovi?, Marija,Koji?-Prodi?, Biserka,Mlinari?-Majerski, Kata
, p. 7985 - 7996 (2007)
Novel adamantane-oxalamide derivatives, N,N′-bis(1-adamantylglycine methyl ester)oxalamide (meso-1 and rac-1), N,N′-bis(3-aminoadamantane-1-carboxylic acid methyl ester)oxalamide (2) and N,N′-bis(3-aminoadamantane-1-carboxylic acid)oxalamide (3) were prepared and structurally characterized by spectroscopic methods and X-ray analysis. Crystal packing of the structures meso-1 and rac-1 is defined by one-dimensional α-networks of hydrogen-bonded chains. The crystal structures of 2 and 3 are characterized by two-dimensional β-networks of hydrogen bonds. The oxalamide 3 crystallizes as the solvates only. In the crystal structure of 3 the protic solvent participates in hydrogen bonding with the oxalamide moieties. However, in non-protic solvents 3 crystallizes as a solvate but the solvent does not participate in hydrogen bonding. The two-dimensional network of hydrogen bonds connecting molecules of 3 generates channels, which are filled by discrete solvent molecules.
NEW ADAMANTANE DERIVATIVES AS DIPEPTIDYL, PEPTIDASE IV INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 50, (2008/06/13)
The present invention relates to dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula (A): wherein R1, R2, Y, and n are as defined herein, pharmaceutical compositions containing the same, processes for their preparation, and methods for treating disorders mediated by DPP-IV inhibition, such as diabetes, especially Type II diabetes, with them.
NITRATION OR CARBOXYLATION CATALYSTS
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, (2008/06/13)
In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the following formula (1): ???wherein R1and R2represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group and a cycloalkyl group, and R1and R2may bond together to form a double bond, or an aromatic or non-aromatic ring, and Y is an O or OH, and n denotes 1 to 3;, a substrate is allowed to contact with at least one reactant selected from (i) a nitrogen oxide and (ii) a mixture of carbon monoxide and oxygen to be introduced with at least one functional group selected from a nitro group and a carboxyl group. The nitrogen oxide includes, for example, a compound represented by the formula NxOy(e.g., N2O3, NO2). The substrate includes, for example, a compound having a methine carbon atom (e.g., adamantane), a compound having a methyl group or a methylene group at an adjacent moiety of an aromatic ring. According to such reaction, the substrate can be efficiently nitrated or carboxylated even in a mild or moderate condition.
