80106-03-2

Upstream product

• 80183-02-4 1-O-tert-butyl-2,3-di-O-p-toluenesulfonyl-D-glycerol 
• 829-85-6 diphenylphosphane 
• 80106-05-4 1-O-tert-butyl-2,3-di-O-p-toluenesulfonylglycerol 

Downstream Products

• 80106-04-3 (R)-1,2-bis(diphenylphosphino)propan-3-ol 

Relevant academic research and scientific papers

Optically active phosphines

The compounds (R)-1,2-bis(diphenylphosphino)-3-benzyloxypropane and (R)-1-tert-butoxy-2,3-bis(diphenylphosphino)propane are precursors to new rhodium-based asymmetric reaction catalysts having the formula: STR1 wherein R is benzyl or tert-butyl.

Chiral 1,2-Diphosphine Ligands. Synthesis and Application to Rhodium-Catalyzed Asymmetric Hydrogenations

New chiral 1,2-diphosphine ligands, (R)-1,2-bis(diphenylphosphino)-3-(benzyloxy)propane and (R)-1,2-bis(diphenylphosphino)-3-tert-butoxypropane, have been prepared from D-mannitol.The rhodium(I) cationic complexes of these ligands are efficient asymmetric homogeneous hydrogenation catalysts for dehydro amino acids, giving (S)-amino acids in high optical yield (80-90percent).