80109-63-3

Usage

Uses

Desoxyquinocetone is a metabolite of the veterinay drug Quinocetone.

Upstream product

• 39145-59-0 o-phenylenediamine hydrochloride 
• 480-96-6 benzofurazan oxide 
• 81810-66-4 1-(3-methyl-1,4-dioxido-2-quinoxalinyl)-3-phenyl-2-propen-1-one 
• 88-74-4 2-nitro-aniline 
• 13297-17-1 3-methyl-2-acetylquinoxaline-1,4-dioxide 
• 22059-64-9 2-methyl-3-acetylquinoxaline 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Improved synthesis of quinocetone and its two deoxy metabolites

Oxidation of o-nitroaniline with sodium hypochlorite afforded benzofurazan oxide in 96 % yield, and treatment of benzofurazan oxide with acetylacetone in the presence of triethylamine gave 2-acetyl-3-methyl-quinoxaline--1,4-dioxide in 94 % yield. Finally, condensation of 2-acetyl-3-methyl-quinox-aline-1,4-dioxide with benzaldehyde using 4-(dimethylamino)pyridinium acetate as a catalyst led to quinocetone in 95 % yield. Subsequently, reduction of the synthesized quinocetone with sodium dithionite resulted in two deoxy derivatives, 1-(3-methyl-4-oxido-2-quinoxalinyl)-3-phenyl-2-propen-1-one and 1-(3-methyl-2-quinoxalinyl)-3-phenyl-2-propen-1-one in 88.5 and 92 % yield, respectively. Furthermore, the synthesized quinocetone, and its deoxy derivatives were characterized by1H-NMR,13C-NMR and elemental analysis.

Metabolic product of four quinocetone chemical synthesis method

The invention relates to a synthetic method of four main metabolites of 2-Propen-1-one-1-(3-methyl-2-quinoxalinyl)-3-phenyl-, 2-Quinoxaline methanol-3-methyl-Alpha-(2-phenylethenyl)-, 2-Propen-1-one-1-(3-methyl-4-oxide-2-quinoxalinyl)-3-phenyl- and 2-Quin

Convenient synthesis of quinocetone metabolites: Characterization, theoretical investigation, and cytotoxicity study

Quinocetone (3-methyl-2-quinoxalinbenzenevinylketo-1,4-dioxide; QCT) is a new promising antimicrobial growth promoter for quinoxalines. The identification of the major metabolites of QCT has resulted in a number of studies regarding its metabolic pathway.

Synthesis of the possible metabolites of quinocetone in animals

The possible metabolites of quinocetone in animals had been prepared with different selective reagent by three synthetic routes. It was their principal reaction that Na2S2O4 reduced quinoxaline-1,4-dioxide derivatives to quinoxaline derivatives, H 2O2 s oxidized 2-carboxyl-quinoxaline derivatives to 2-carboxyl-quinoxaline-1 -oxide ones and P(OCH3) 3 reduced 2-carboxyl- quinoxaline-1,4-dioxide derivatives to 3-carboxyl-quinoxaline-1-oxide ones. The title compounds ware confirmed with NMR,UV, FAB-MS, et al.