801218-75-7

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 110865-03-7 2-chloro-1-(2,4,6-trihydroxyphenyl)ethan-1-one 
• 801218-76-8 7-difluoromethoxy-2-(4-difluoromethoxy-phenyl)-5-hydroxy-chromen-4-one 

Downstream Products

• 801218-73-5 7-difluoromethoxy-2-(4-difluoromethoxy-phenyl)-6-iodo-5-methoxy-chromen-4-one 

Relevant academic research and scientific papers

Synthesis of gem-difluoromethylenated biflavonoid via the Suzuki coupling reaction

gem-Difluoromethylenated biflavonoid 1 was synthesized via the Suzuki coupling reaction. The key intermediate 6-iodonated flavone 4 was regioselectively synthesized by the use of AgOAc/I2 under mild conditions without handling of a strongly toxic reagent. The key step was the formation of a flavone 3′-boronate 3 using a palladium-catalyzed exchange of the corresponding 3′-iodonated flavone with a diboron reagent.