801283-11-4Relevant academic research and scientific papers
A one-pot selective synthesis of N-Boc protected secondary amines: Tandem direct reductive amination/N-Boc protection
Neelarapu, Raghupathi,Petukhov, Pavel A.
, p. 7056 - 7062 (2012)
A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)2O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected secondary amines even in those cases where the products are prone to intramolecular lactamization.
