80134-26-5

Upstream product

• 1089-80-1 3-hydroxy-estra-1,3,5⁽¹⁰⁾,9⁽¹¹⁾-tetraen-17-one 
• 100-39-0 benzyl bromide 
• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 

Downstream Products

• 80134-28-7 3-benzyloxy-17,17-ethylenedioxyestra-1,3,5(10)-trien-11α-ol 
• 80134-29-8 3-benzyloxy-11α-(2-N,N-diethylaminoethyloxy)-17,17-ethylenedioxyestra-1,3,5(10)-triene 
• 80134-27-6 3-benzyloxy-17,17-ethylenedioxyestra-1,3,5⁽¹⁰⁾,9⁽¹¹⁾-tetraene 

Relevant academic research and scientific papers

Functionalisations of estrone benzyl ether at the 11 and 12 positions

The prior protection of estrone as estrone benzyl ether (EBE) facilitated the 9,11 dehydrogenation by DDQ, which is a key step for the 11 functionalisation. The oxidation of estrone benzyl ether by an excess of DDQ in dioxane containing a small amount of methanol allowed for an unusual 12 functionalisation with a methoxy group. (C) 2000 Elsevier Science Ltd.

Synthesis of 11&α- and 11&β-Diethylaminoethyl Ethers of 17&α-Ethynylestradiol

The 11α- and 11β-diethylaminoethyl ethers of 17α-ethynylestradiol have been prepared from the intermediate alcohols (7a) and (7b) by direct alkylation with 2-N,N-diethylaminoethyl bromide hydrobromide followed by hydrogenolysis, deacetalization, and react