80140-15-4Relevant academic research and scientific papers
SULFONAMIDE DERIVATIVES
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, (2008/06/13)
The object is to provide a compound having matrixmetalloproteinase-13 inhibitory activity and aglycanase inhibitory activity. A compound of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:{R1: H, NHOH; R2: H, optionally substituted alkyl, cycloalkyl, a group -AR6 [A: an alkylene which may be optionally interrupted by O, -S(O)m- or -N(R9); R6: a group (II), (III), (IV)X: O, S, -N(R10)-, -C(R11)(R12)-; Y: O, CO, -S(O)n-, -N(R10)-, -C(R11)(R12)-; R7, R8: H, alkyl, COOH, optionally subsituted alkyl, etc.; R9, R10, R11,R12: H, alkyl, etc.; m, n: 0 to 2]R3: H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl; R4: optionally substituted (hetero)arylene; R5: optionally substituted alkyl, optionally substituted (hetero)aryl}.
Synthesis of chiral carbocyclic ribonucleotides
Antle, Vincent D.,Caperelli, Carol A.
, p. 1911 - 1928 (2007/10/03)
The carbocyclic analogs of CMP, UMP, GMP, IMP, and ribo-TMP, of the same absolute configuration as the naturally occurring β-D-ribofuranose-based ribonucleoside monophosphates, have been synthesized. The synthetic route employed Mitsunobu coupling of the
Synthesis of acyclic analogs of pyrimidine nucleosides with aromatic units in the side chain
Novikov,Ozerov,Brel',Solodunova,Ozerova
, p. 328 - 332 (2007/10/03)
The synthesis of some pyrimidine acyclonucleotides with aromatic units in the side chain has been accomplished. Their physicochemical and spectroscopic properties have been studied. These compounds may be described as the substances with potential as antiviral and anticancer activity. 1996 Plenum Publishing Corporation.
Acyclic nucleosides: Synthesis of 1-[(1-hydroxy-2-propoxy)methyl]thymine, 6-azathymine, uracil, and 6-azauracil as potential antiviral agents
Wang,Chen,Tzeng
, p. 1201 - 1213 (2007/10/02)
A series of acyclic nucleosides have been synthesized. Thymine, 6- azathymine, uracil, and 6-azauracil were silylated with hexamethyldisilazane in the presence of ammonium sulfate and then coupled with 1-benzyloxy-2- chloromethoxypropane to give the corresponding 1-(1-benzyloxy-2- propoxy)methyl derivatives. A minor quantity of benzyloxymethylated product was also obtained in each case. Hydrogenolysis of the protected acyclic nucleosides with palladium(II) hydroxide afforded the title compounds. None of the compounds exhibited significant antiviral activity against human immunodeficiency virus (HIV).
