80193-04-0Relevant articles and documents
Synthesis method of cyclopentane-1,2-dicarboximide
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, (2018/10/19)
The invention discloses a synthesis method of cyclopentane-1,2-dicarboximide. The synthesis method comprises the following steps: performing dehydration on cyclohexanone and urea as raw materials under the actions of a polymerization inhibitor and a water-carrying agent, heating, dropwise adding an acid liquor for hydrolyzing, adding an alcoholic solvent in the hydrolyzed solution, crystallizing,centrifuging, and drying to obtain cyclohexane-2-carboxamide, dissolving cyclohexane-2-carboxamide in halogenated hydrocarbon, performing halogenation under a halogenation reagent, performing cooling,crystallizing, hydrolyzing, centrifuging and drying to obtain a halide, dispersing the halide in an ammoniating solution for Favorskii rearrangement, sequentially performing cooling, crystallizing, centrifuging, washing and drying to obtain a rearrangement object, namely cyclopentane-1,2-carboxamide, finally adding a proper amount of catalysts, and after high temperature cyclization, performing reduced pressure distillation, performing refined crystallization, centrifuging, and drying, thereby obtaining cyclopentane-1,2-dicarboximide. The synthesis method has the advantages that the reactionstep is shortened, the environmental protection is benefited, the production cost is reduced, and the synthesis method is suitable for large-scale mass production.
