75806-84-7 Usage
General Description
2-Bromo-3-chloro-5-(trifluoromethyl)pyridine is a chemical compound with the formula C6H2BrClF3N. It is a pyridine derivative that contains bromine, chlorine, and a trifluoromethyl group. 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine is commonly used in the pharmaceutical and agrochemical industries as an intermediate for the synthesis of various compounds. It has been found to exhibit pesticidal and herbicidal activities, making it a valuable building block for the development of new agricultural products. Additionally, it can also be used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity and functionality. Its unique combination of functional groups and potential applications make 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine a valuable compound in the field of organic chemistry and chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 75806-84-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,8,0 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 75806-84:
(7*7)+(6*5)+(5*8)+(4*0)+(3*6)+(2*8)+(1*4)=157
157 % 10 = 7
So 75806-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H5F7N2/c1-3-2-4(16-15-3)5(8,9)6(10,11)7(12,13)14/h2H,1H3,(H,15,16)
75806-84-7Relevant articles and documents
A for the synthesis of anti-cancer auxiliary drug pyridine medical process for the preparation of intermediates
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Paragraph 0026, (2017/01/26)
The invention relates to the field of medical chemistry and discloses a method for synthesizing a pyridine medical intermediate, namely 2-bromo-3-chloro-5-trifluoromethyl pyridine, for synthesizing anti-cancer auxiliary medicines. The method comprises the following steps of: (1) reacting 6-hydroxynicotinic acid, hydrofluoric acid and sulfur tetrafluoride at the temperature of between 100 and 120DEG C and under the pressure of 0.1-0.3MPa, and adding water to obtain 2-hydroxy-5-trifluoromethyl pyridine; (2) reacting with N-chlorosuccinimide, and performing water precipitation to obtain 3-chloro-5-trifluoromethyl-2-hydroxypyridine; and (3) adding excessive phosphorus oxybromide, reacting at the temperature of between 145 and 160DEG C for 5 to 8 hours, cooling, violently stirring at the temperature of between -5 and 0DEG C, extracting, combining organic phases, drying, filtering, performing spin drying, and purifying by using a silica gel column. According to the method, raw materials are readily available, the cost is low, the method is suitable for industrial production and the yield exceeds 38 percent.